Plasma Desorption Mass Spectrometry — Achievements and Frontiers

  • Bo U. R. Sundqvist
  • Per Håkansson
  • Allan Hedin
  • David Fenyö
  • Gunnar Brinkmalm
  • Peter Roepstorff
  • Robert E. Johnson
Part of the NATO ASI Series book series (NSSB, volume 269)


Almost twenty years ago, R.D. Macfarlane, D.F. Torgerson and others at Texas A&M discovered that fission fragments from a 252Cf source can cause ejection of whole intact molecular ions from a sample consisting of a multi-layer deposit of organic molecules [1]. The secondary ions were mass analyzed with a time-of-flight (TOF) technique. The potential of the new mass spectrometric method, called Plasma Desorption Mass Spectrometry (PDMS) was demonstrated in a number of experiments by the Texas group but it was not until almost ten years later when the full potential for high mass analysis was demonstrated [2,3], in fact almost coinciding with the appearance of the FAB method [4], that the method started to be used more extensively in mass spectrometry applications. In fact the use of adsorption of sample molecules to a substrate of nitrocellulose [5] was probably the singly most important reason why PDMS started to be used as a tool in protein chemistry. In establishing the potential of the method important contributions, in addition to those at Texas A&M university were made by Field and Chait [6] at Rockefeller university and by the Uppsala-Odense collaboration [7]. Already a few years after the Texas discovery groups at Darmstadt [8], Orsay [9], Erlangen [10] and Uppsala [11] started to use accelerators, in addition to 252Cf, to study various aspects of the basic mechanisms involved in PDMS.


Fission Fragment High Charge State Field Free Region Large Organic Molecule Renin Substrate 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    D.F. Torgerson, R.P. Skowronski and R.D. Macfarlane, Biophys. Res. Commun. 60 (1974) 616.CrossRefGoogle Scholar
  2. 2.
    P. Håkansson, I. Kamensky, B. Sundqvist, J. Fohlman, P. Peterson, C.J. McNeal and R.D. Macfarlane, J. Am. Chem. Soc. 104 (1982) 2948.CrossRefGoogle Scholar
  3. 3.
    C.J. McNeal, R.D. Macfarlane, J. Am. Chem. Soc. 103 (1981) 1609CrossRefGoogle Scholar
  4. 4.
    M. Barber, R.S Bordoli, R. Sedgwick and A.N. Tyler, J. Chem. Soc. Chem. Commun. (1981) 325.Google Scholar
  5. 5.
    G.A. Jonsson, A.B. Hedin, P.L. Håkansson, B.U.R. Sundqvist, G. Säve, P. Roepstorff, P. Nielsen, K.E. Johansson, I. Kamensky, M.S. Lindberg, Anal. Chem. 58 (1986) 1084CrossRefGoogle Scholar
  6. 6.
    B.T. Chait, W.C. Agosta, F.H. Field, Int. J. Mass Spectrom. Ion Phys. 41 (1981) 17.CrossRefGoogle Scholar
  7. 7.
    B. Sundqvist, P. Håkansson, I. Kamensky, J. Kjellberg, M. Salehpour, S. Widdiyasekera, J. Fohlman, P. Peterson and P. Roepstroff, Biomed. Mass Spectrom. 11 (1984) 242.CrossRefGoogle Scholar
  8. 8.
    W. Guthier, O. Becker, W. Knippelberg, U. Weikert, K. Wien, J. Della Negra, Y. LeBeyec, P. Weiser, R. Wurster, Int. J. Mass Spectrom. Ion Phys. 53 (1983) 185.ADSCrossRefGoogle Scholar
  9. 9.
    S. Della Negra, D. Jaquet, I. Lorthiosis, Y. LeBeyec, O. Becker and K. Wien, Int. J. Mass Spectrometry Ion Phys. 53 (1983) 215.ADSCrossRefGoogle Scholar
  10. 10.
    P. Dück, W. Treu, W. Galster, H. Fröhlich and H. Voit, Nucl. Instrum. Methods 168 (1980) 601.CrossRefGoogle Scholar
  11. 11.
    P. Håkansson and B. Sundqvist, Rad. Eff. 61 (1982) 179.CrossRefGoogle Scholar
  12. 12.
    M. Alai, P. Demirev, C. Fenselau and R.J. Cotter, Anal. Chem. 58 (1986) 1303CrossRefGoogle Scholar
  13. 13.
    M. Karas and F. Hillenkamp, Anal. Chem. 60 (1988) 2299.CrossRefGoogle Scholar
  14. 14.
    J.B. Fenn, M. Mann, C.K. Meng, S.F. Wong and CM. Whitehouse, Science 246 (1989) 64.ADSCrossRefGoogle Scholar
  15. 15.
    B. Sundqvist, Nucl. Instrum. Meth. B48 (1990) 517ADSGoogle Scholar
  16. 16.
    M. Salehpour, P. Håkansson, B. Sundqvist and S. Widdiyasekera, Nucl. Instr. and Meth. B13 (1986) 278.ADSGoogle Scholar
  17. 17.
    A. Hedin, P. Håkansson, M. Salehpour and B.U.R Sundqvist, Phys. Rev. B35 (1987) 7377ADSGoogle Scholar
  18. 18.
    G. Säve, P. Håkansson, B.U.R. Sundqvist, E. Söderström, S.E. Lindqvist and J. Berg, Appl. Phys. Lett. 51 (1987) 1379.ADSCrossRefGoogle Scholar
  19. 19.
    G. Bolbach, S. Della Negra, D. Deprun, Y. LeBeyec and K.G. Standing, Rapid Commun. Mass Spectrom. 1 (1987) 22.CrossRefGoogle Scholar
  20. 20.
    B. Sundqvist, A. Hedin, P. Håkansson, I. Kamensky, J. Kjellberg, M. Salehpour, G. Säve and S. Widdiyasekera, Int. J. Mass Spectrom. Ion Phys. 53 (1983) 167.ADSCrossRefGoogle Scholar
  21. 21.
    G Jonsson, A. Hedin, P. Håkansson, B.U.R. Sundqvist, H. Bennich and P. Roepstorff, Rapid Commun. Mass Spec. 3 (1989) 190.CrossRefGoogle Scholar
  22. 22.
    W. Ens, B.U.R. Sundqvist, A. Hedin, P. Håkansson and G. Jonsson, Phys. Rev. B39 (1989) 763.ADSGoogle Scholar
  23. 23.
    R. Mosshammer, R. Matthäus, K. Wien and G. Bolbach, in “Proceedings of Ion Formation from Organic Solids V (IFOS V)”, eds. A. Hedin, B. U. R. Sundqvist and A. Benninghoven, J. Wiley & Sons Ltd, Chichester (1990) p. 17Google Scholar
  24. 24.
    D. Fenyö, A. Hedin P. Håkansson and B. U. R. Sundqvist, Int. J. Mass Spectrom. Ion Proc. 100 (1990) (in print)Google Scholar
  25. 25.
    LS. Bitenski and E.S. Parilis, Nucl. Instr. and Meth. B21 (1987) 26.Google Scholar
  26. 26.
    P. Williams and B.U.R. Sundqvist, Phys. Rev. Lett. 58 (1987) 1031.ADSCrossRefGoogle Scholar
  27. 27.
    E.R. Hilf, H.F. Kammer and B. Nitzschmann, in “Ion Formation from Organic Solids (IFOS IV)”, ed. A. Benninghoven, Wiley, Chichester (1989) p. 97.Google Scholar
  28. 28.
    D. Fenyö, B. Sundqvist, B. Karlsson and R.E. Johnson, Phys. Rev. B42(1990) 1895.ADSGoogle Scholar
  29. 29.
    R. E. Johnson, J. Phys. C2 (1989) 251Google Scholar
  30. 30.
    R.E. Johnson, B.U.R. Sundqvist, A. Hedin and D. Fenyö, Phys. Rev. B39 (1989) 763.ADSGoogle Scholar
  31. 31.
    P.K. Haff, Appl. Phys. Lett. 29 (1976) 473.ADSCrossRefGoogle Scholar
  32. 32.
    R.E. Johnson and B.U.R. Sundqvist, Int. J. Mass Spectrom. Ion Phys. 53 (1983) 337.ADSCrossRefGoogle Scholar
  33. 33.
    E.A. Jordan, R.D. Macfarlane, R.D. Martin and C.R. McNeal, Int. J Mass Spectrom. Ion Phys. 53 (1983) 345ADSCrossRefGoogle Scholar
  34. 34.
    G. Jonsson, A. Hedin, P. Hâkansson and B.U.R. Sundqvist, Rapid Comm. Mass Spec. 2 (1988) 154.CrossRefGoogle Scholar
  35. 35.
    B.T. Chait and F.H. Field, Biochem. Biophys. Res. Commun. 134 (1986) 420CrossRefGoogle Scholar
  36. 36.
    P. Roepstorff, Acc. Chem. Res. 22 (1989) 421CrossRefGoogle Scholar
  37. 37.
    X. Tang, R. Beavis, W. Ens, F. Lafortune, B. Schueler and K.G. Standing, Int. J. Mass Spectrom. Ion. Proc. 85 (1988) 43CrossRefGoogle Scholar
  38. 38.
    P. Hâkansson, G. Brinkmalm, J. Kjellberg and B.U.R. Sundqvist (to be published)Google Scholar
  39. 39.
    C.J. McNeal and R.D. Macfarlane, in “Proceedings of Ion Formation from Organic Solids IV (IFOS IV)”, ed. A. Benninghoven, J. Wiley &Sons, Chichester (1989) p. 63Google Scholar
  40. 40.
    G. Jonsson, G. Brinkmalm, B.U.R. Sundqvist, A. Hedin and P. Hâkansson, TSL-ISV:21, ISSN 0284–2769, Uppsala university 1989Google Scholar
  41. 41.
    A. Hedin, private communication.Google Scholar
  42. 42.
    M. Mann, C.K. Meng and J.B. Fenn, Anal. Chem. 61 (1989) 1702CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Bo U. R. Sundqvist
    • 1
  • Per Håkansson
    • 1
  • Allan Hedin
    • 1
  • David Fenyö
    • 1
  • Gunnar Brinkmalm
    • 1
  • Peter Roepstorff
    • 2
  • Robert E. Johnson
    • 3
  1. 1.Div. of Ion Physics, Dept. of Radiation SciencesUppsala UniversityUppsalaSweden
  2. 2.Dept. of Molecular BiologyOdense UniversityOdenseDenmark
  3. 3.School of EngineeringUniversity of VirginiaCharlottesvilleUSA

Personalised recommendations