Neuroanatomy pp 582-597 | Cite as

An Intricately Patterned Prefronto-Caudate Projection in the Rhesus Monkey

  • Patricia S. Goldman
  • Walle J. H. Nauta
Part of the Contemporary Neuroscientists book series (CN)


The distribution of prefronto-caudate fibers in the caudate nucleus was studied autoradiographically in monkeys of various ages in which tritiated amino acids had been injected into the middle one-third of the length of the dorsal bank of the principal sulcus. The results indicate that, contrary to previous reports which had suggested a projection to only the head of the caudate nucleus, area 9 of Brodmann projects to the entire length of the nucleus.

In the head of the caudate nucleus the cortico-caudate fibers are distributed in a pattern which is remarkable in two respects. First, the grains are not uniformly distributed but rather are segregated into clusters separated from one another by territories in which grain density does not exceed background. Second, individual clusters of grains, circular or elliptical in shape, surround grain free cores. These patterns of fiber distribution within the head of the nucleus are more sharply defined in newborn than in older monkeys. Our findings suggest that the caudate nucleus is organized more as an anatomic and functional mosaic than as the homogeneously organized structure that it is commonly considered to be.


Prefrontal Cortex Caudate Nucleus Superior Colliculus Efferent Connection Adult Monkey 
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Literature Cited

  1. Carman, J. B., W. M. Cowan and T. P. S. Powell 1963 The organization of corticostriate connections in the rabbit. Brain, 86: 525–560.CrossRefGoogle Scholar
  2. De Vito, J. L., and O. A. Smith, Jr. 1964 Subcortical projections of the prefrontal lobe of the monkey. J. Comp. Neur., 123: 413–424.CrossRefGoogle Scholar
  3. Goldman, P. S., and W. J. H. Nauta 1977 Columnar distribution of cortico-cortical fibers in the motor, frontal association, and limbic cortex of the immature and adult monkey. Brain Res., in press.Google Scholar
  4. Goldman, P. S., and W. J. H. 1976 Autoradiographic demonstration of a projection from prefrontal association cortex to the superior colliculus. Brain Res., 116: 145–149.CrossRefGoogle Scholar
  5. Graybiel, A. M. 1975 Anatomical organization of retinotectal afferents in the cat: an autoradiographic study. Brain Res., 96: 1–24.CrossRefGoogle Scholar
  6. Graybiel, A. M, and T. R. Sciascia 1975 Origin and distribution of nigrotectal fibers in the cat. Neurosci., 1: 174, (Abstract).Google Scholar
  7. Hubel, D. H., S. LeVay and T. N. Wiesel 1975 Mode of termination of retino-tectal fibers in macaque monkey: an autoradiographic study. Brain Res., 96; 25–40.CrossRefGoogle Scholar
  8. Johnson, T. N., H. E. Rosvold, T. W. Galkin and P. S. Goldman 1976 Postnatal maturation of subcortical projections from the prefrontal cortex in the rhesus monkey. J. Comp. Neur., 166: 427–444.CrossRefGoogle Scholar
  9. Johnson, T. N., H. E. Rosvold and M. Mishkin 1968 Projections from behaviorally-defined sectors of the prefrontal cortex to the basal ganglia, septum and diencephalon of the monkey. Exp. Neurol., 21: 20–34.CrossRefGoogle Scholar
  10. Kemp, J. M., and T. P. S. Powell 1970 The cortico-striate projection in the monkey. Brain, 93: 525–546.CrossRefGoogle Scholar
  11. Kemp, J. M., and T. P. S. Powell 1971a The site of termination of afferent fibers in the caudate nucleus. Phil. Trans. R. Soc. Lond. (B), 262: 413–427.CrossRefGoogle Scholar
  12. Kemp, J. M., and T. P. S. Powell 1971b The termination of fibers from the cerebral cortex and thalamus upon dendritic spines in the caudate nucleus: a study with the Golgi method. Phil. Trans. R. Soc., Lond. (B), 262: 429–439.CrossRefGoogle Scholar
  13. Künzle, H. 1975 Bilateral projections from pre-central motor cortex to the putamen and other parts of the basal ganglia. Brain Res., 88: 195–210.CrossRefGoogle Scholar
  14. Nauta, W. J. H. 1964 Some efferent connections of the prefrontal cortex in the monkey. In: The Frontal Granular Cortex and Behavior. J. M. Warren and K. Akert, eds. McGraw-Hill, New York, pp. 397–409.Google Scholar
  15. Olson, L., Å. Seiger and K. Fuxe 1972 Heterogeneity of striatal and limbic dopamine innervation: Highly fluorescent islands in developing and adult rats. Brain Res., 44: 283–288.CrossRefGoogle Scholar
  16. Petras, J. M. 1969 Some efferent connections of the superior and inferior parietal lobules with the basal ganglia, diencephalon and midbrain in the rhesus monkey. Anat. Rec., 163: 243–244.Google Scholar
  17. Széntágothai, J. 1970 Glomerular synapses, complex synaptic arrangements, and their operational significance. In: The Neurosciences, Second Study Program. F. O. Schmitt, ed. The Rockefeller University Press, New York, pp. 427–443.Google Scholar
  18. Webster, K. E. 1961 Cortico-striate interrelations in the albino rat. J. Anat. (London), 95: 532–545.Google Scholar
  19. Webster, K. E. 1965 The cortico-striatal projection in the cat. J. Anat. (London), 99: 329–337.Google Scholar
  20. Whitlock, D. G., and W. J. H. Nauta 1956 Subcortical projections from the temporal neocortex in Macaca mulatta. J. Comp. Neur., 106: 183–212.CrossRefGoogle Scholar

Copyright information

© The Wistar Institute Press 1977

Authors and Affiliations

  • Patricia S. Goldman
    • 1
    • 2
  • Walle J. H. Nauta
    • 1
    • 2
  1. 1.Laboratory of NeuropsychologyNational Institute of Mental HealthBethesdaUSA
  2. 2.Department of PsychologyMassachusetts Institute of TechnologyCambridgeUSA

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