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Molecular Mechanisms of Membrane Fusion and Applications of Membrane Fusion Techniques

  • Jan Wilschut
  • Janny Scholma
  • Toon Stegmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

The functioning of all eukaryotic cells is critically dependent on a variety of membrane fusion phenomena. For example, membrane fusion plays a key role not only in such cell-cell fusion events as fertilization and myogenesis, but also in intracellular transport processes, involving specific fusion events between membrane vesicles derived from various cellular compartments. This vesicular fusion appears to be a general trafficking mechanism in the sorting of cellular components during membrane biogenesis and the assembly of cell organelles. Vesicular fusion also plays a central role in the internalization of compounds from the extracellular environment through endocytosis, and their subsequent intracellular processing, and in the exocytotic secretion of products synthesized by the cell. Finally, membrane fusion is a crucial step in the infectious entry of enveloped viruses into cells.

Keywords

Influenza Virus Membrane Fusion Phospholipid Vesicle Erythrocyte Ghost Fusion Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Jan Wilschut
    • 1
  • Janny Scholma
    • 1
  • Toon Stegmann
    • 1
  1. 1.Laboratory of Physiological ChemistryUniversity of GroningenGroningenThe Netherlands

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