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Biotechnological Applications of Lipid Microstructures pp 105–126Cite as

Molecular Mechanisms of Membrane Fusion and Applications of Membrane Fusion Techniques

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 238))

Abstract

The functioning of all eukaryotic cells is critically dependent on a variety of membrane fusion phenomena. For example, membrane fusion plays a key role not only in such cell-cell fusion events as fertilization and myogenesis, but also in intracellular transport processes, involving specific fusion events between membrane vesicles derived from various cellular compartments. This vesicular fusion appears to be a general trafficking mechanism in the sorting of cellular components during membrane biogenesis and the assembly of cell organelles. Vesicular fusion also plays a central role in the internalization of compounds from the extracellular environment through endocytosis, and their subsequent intracellular processing, and in the exocytotic secretion of products synthesized by the cell. Finally, membrane fusion is a crucial step in the infectious entry of enveloped viruses into cells.

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  1. Toon Stegmann

    Present address: Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA

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  1. Laboratory of Physiological Chemistry, University of Groningen, Bloemsingel 10, 9712 KZ, Groningen, The Netherlands

    Jan Wilschut, Janny Scholma & Toon Stegmann

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  1. Naval Research Laboratory, Washington, D.C., USA

    Bruce Paul Gaber  & Joel M. Schnur  & 

  2. Royal Free Hospital School of Medicine, London, UK

    Dennis Chapman

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Wilschut, J., Scholma, J., Stegmann, T. (1988). Molecular Mechanisms of Membrane Fusion and Applications of Membrane Fusion Techniques. In: Gaber, B.P., Schnur, J.M., Chapman, D. (eds) Biotechnological Applications of Lipid Microstructures. Advances in Experimental Medicine and Biology, vol 238. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7908-9_9

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