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Surfactant-Induced Liposome Fusion: Molecular Mechanisms and Biotechnological Applications

  • Félix M. Goñi
  • Alicia Alonso
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

Membrane fusion is an essential event in many important physiological and pathological processes, such as neurotransmitter release, endocrine secretion, certain viral infections, etc. The molecular mechanism of membrane fusion remains still unknown; early studies suggested that amphipathic molecules could be involved1; some recent evidence2,3 supports earlier suggestions of the involvement of osmotic phenomena in membrane fusion; changes in water activity at the cell-water interface have also been invoked4. In our studies, we have examined in particular the possible role of water-soluble amphiphiles (i.e. surfactants), in the fusion process: a whole series of hydro-phyllic and lipophyllic surface active reagents have been tested for fusogenic activity by other authors5.

Keywords

Mixed Micelle Membrane Fusion Cated Liposome Maximum Turbidity Vesicle Fusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Félix M. Goñi
    • 1
  • Alicia Alonso
    • 1
  1. 1.Departamento de Bioquímica, Facultad de CienciasUniversidad del País VascoBilbaoEspaña

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