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Biotechnological Applications of Lipid Microstructures pp 81–103Cite as

Surfactant-Induced Liposome Fusion: Molecular Mechanisms and Biotechnological Applications

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 238))

Abstract

Membrane fusion is an essential event in many important physiological and pathological processes, such as neurotransmitter release, endocrine secretion, certain viral infections, etc. The molecular mechanism of membrane fusion remains still unknown; early studies suggested that amphipathic molecules could be involved1; some recent evidence2,3 supports earlier suggestions of the involvement of osmotic phenomena in membrane fusion; changes in water activity at the cell-water interface have also been invoked4. In our studies, we have examined in particular the possible role of water-soluble amphiphiles (i.e. surfactants), in the fusion process: a whole series of hydro-phyllic and lipophyllic surface active reagents have been tested for fusogenic activity by other authors5.

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Author information

Authors and Affiliations

  1. Departamento de Bioquímica, Facultad de Ciencias, Universidad del País Vasco, Apdo. 644, 48080, Bilbao, España

    Félix M. Goñi & Alicia Alonso

Authors
  1. Félix M. Goñi
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  2. Alicia Alonso
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Editor information

Editors and Affiliations

  1. Naval Research Laboratory, Washington, D.C., USA

    Bruce Paul Gaber  & Joel M. Schnur  & 

  2. Royal Free Hospital School of Medicine, London, UK

    Dennis Chapman

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© 1988 Plenum Press, New York

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Goñi, F.M., Alonso, A. (1988). Surfactant-Induced Liposome Fusion: Molecular Mechanisms and Biotechnological Applications. In: Gaber, B.P., Schnur, J.M., Chapman, D. (eds) Biotechnological Applications of Lipid Microstructures. Advances in Experimental Medicine and Biology, vol 238. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7908-9_8

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  • DOI: https://doi.org/10.1007/978-1-4684-7908-9_8

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  • Print ISBN: 978-1-4684-7910-2

  • Online ISBN: 978-1-4684-7908-9

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