Molecular Modeling of the Phospholipid Bilayer
We have developed computer graphics models of the phospholipid bilayer which are based upon published X-ray crystallographic data. We believe that these depictions convey significantly more information about the structure and chemistry of lipid molecules and bilayers than do the iconographic or schematic representations of the past. These graphic models, beyond their utility for visualization of structure, provide a starting point for subsequent higher level molecular modeling (molecular mechanics, graphics and dynamics) of systems including polymerizable lipids, bilayer/small molecule complexes and lipid/protein interactions.
KeywordsAcyl Chain Lipid Molecule Phospholipid Bilayer Naval Research Laboratory DMPC Bilayer
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- Chandrasekhar, I. and Gaber, B. P., Stabilization of the Bio-Membrane by Small Molecules: Interaction of Trehalose with the Phospholipid Bilayer, J. Biomol. Stereodynam., in press.Google Scholar
- Jarvis, L., Huang, C., Ferrin, T., and Langridge, R., 1985, “Midas Users’ Manual,” Computer Graphics Laboratory, University of California-San Francisco.Google Scholar
- Leopold, A. C., ed., 1986, “Membranes, Metabolism and Dry Organisms,” Cornell University Press, Ithaca, New York.Google Scholar
- Rudolph, A. S., Singh, B. P., Singh, A., and Burke, T. G., Phase characteristics of Positional Isomer of 1,2-Bis Heptacosadiynoyl-sn-Glycero-3-Phosphocholine Tubules, submitted to Biochim. Biophys. Acta.Google Scholar