Skin Permeability and Models of Percutaneous Absorption

  • Hans Schaefer
  • Chris Hensby
Part of the NATO ASI Series book series (NSSA, volume 181)


Whilst being continually exposed to a wide variety of chemical and physical insults, skin, which is the largest organ of the body, acts as an effective barrier to these insults. Consequently there are relatively minimal incidences of either local or systemic effects due to such exposure.


Barrier Function Normal Skin Percutaneous Absorption Niflumic Acid Skin Permeability 


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  1. 1.
    Scheuplein, R.J. 1967 J. Invest. Dermatol. 48, 79–88.Google Scholar
  2. 2.
    Scheuplein, R.J. 1978 in: The Physiology and Pathophysiology of the skin 5. Ed. A. Jarret Academic Press, London.Google Scholar
  3. 3.
    Walters, K.A. 1986, Pharmaceutical Technology, 10, 30–46.Google Scholar
  4. 4.
    Schaefer, H.; Wepierre, J.; Illel, B. and Doucet, O. 1989 Skin Pharmacology (in Press).Google Scholar
  5. 5.
    Schaefer, H. 1985 Arch. Dermatol. 121, 1505–1508.PubMedCrossRefGoogle Scholar
  6. 6.
    Scheuplein, R.J. and Blank, I.H. 1971 Physiol. Rev. 51, 702–747.PubMedGoogle Scholar
  7. 7.
    Finnen, M. 1987 in Pharmacol. Skin Ed. Shroot, B. and Schaefer, H. Karger, Basel pp 163–169.Google Scholar
  8. 8.
    Tauber, U. and Rost, K.L. 1987 in Pharmacol. Skin Ed. Shroot, B. and Schaefer, H. Karger, Basel pp 170–183.Google Scholar
  9. 9.
    Kranz, G.; Schaefer, H. and Zesch, A. 1977 Acta. Derm. Veneorol. 57 269.Google Scholar
  10. 10.
    Rougier, A.; Dupuis, D., Rouget, R. and Schaefer, H. 1983 J. Invest. Dermatol. 81, 275–278.Google Scholar
  11. 11.
    Schaefer, H. and Lamaud, E. 1987 Pharmacol Skin Ed Shroot, B. and Schaefer, H. pp 77–80.Google Scholar
  12. 12.
    Franz, J.J. 1975 J. Invest. Dermatol. 64 190–195.Google Scholar
  13. 13.
    Cooper, E.R. and Berner, B. 1985 in Methods in Skin Research, Eds Skerrow, D. and Skerrow, C.J.; Wiley J. and Son pp 407–432.Google Scholar
  14. 14.
    Schaefer, H.; Zech, A. and Stuttgen, G. 1982 Skin Permeability Springer Verlag Berlin.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Hans Schaefer
    • 1
  • Chris Hensby
    • 1
  1. 1.Centre International de Recherches Dermatologiques (C.I.R.D.)Valbonne cédexFrance

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