Chemical-Induced Differentiation of Cultured Human Keratinocytes as Measured by Cell Size Distribution

  • Frank Van Pelt
  • Marion Stelling
  • Ine Hassing
  • Ruud Van De Heijden
  • Bas Blaauboer
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 181)


Polyhalogenated aromatic hydrocarbons (including dibenzo-p-dioxins, dibenzofurans, biphenyls and azobenzenes) can induce alteration of the differentiation pattern of the epithelial cells in target tissues [1]. The toxicity of polyhalogenated aromatic hydrocarbons depends on the number and position of the halogen atoms [1]. Especially those compounds substituted on the lateral positions of the rings are able to induce a variety of toxic responses. The most common effect in all species is the wasting syndrome, marked by a reduction in body weight and adipose tissue. Thymus atrophy and hepatomegaly are frequently observed in all species after dioxin exposure. Other toxic responses, such as skin and gastric lesions, are regarded as more species specific [1].


Aromatic Hydrocarbon Terminal Differentiation Human Keratinocytes Minimal Effective Concentration Cell Size Distribution 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Frank Van Pelt
    • 1
    • 2
  • Marion Stelling
    • 1
  • Ine Hassing
    • 1
  • Ruud Van De Heijden
    • 1
  • Bas Blaauboer
    • 1
  1. 1.Research Institute of ToxicologyUniversity of Utrechtthe Netherlands
  2. 2.RCC Notox BV’s-Hertogenboschthe Netherlands

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