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An Interspecies Comparison of Skin Structure (Hair Follicle Area as Determined by a Novel Technique) and Skin Permeability

  • F. M. Smith
  • R. C. Scott
  • J. R. Foster
Part of the NATO ASI Series book series (NSSA, volume 181)

Abstract

A number of factors are believed to be important in determining the percutaneous absorption of chemicals. These include the thickness of the stratum corneum and living epidermis, the physicochemical characteristics of compounds, and perhaps, the size and density of hair follicles. The accurate measurement of hair follicle density poses difficulties in species that have relatively high (eg. the rat), or low (eg. man) follicular densities.

Keywords

Hair Follicle Skin Sample Percutaneous Absorption Hair Shaft Glycol Ether 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Absorption of some glycol ethers through human skin in vitro.Google Scholar
  2. P.H. Dugard, M. Walker, S.J. Mawdsley and. R.C. Scott. Environ. Health Persp. 57, 193–197 (1984).CrossRefGoogle Scholar
  3. Mechanism of percutaneous absorptions II Transient diffusion and the relative importance of various routes of skin penetration. R.J. Scheuplein. Journal of Invest. Dermatol. 48, 79–88 (1967).Google Scholar
  4. Methods for in vitro percutaneous absorption studies: II Animal models for human skin. R.L. Bronaugh, R.F. Stewart and; E.R. Congdon Tox. Appl. Pharmacol. 62, 481–488 (1982).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • F. M. Smith
    • 1
  • R. C. Scott
    • 1
  • J. R. Foster
    • 1
  1. 1.Central Toxicology LaboratoryMacclesfield, CheshireUK

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