Nuclear Aberrations in Anagen Hair Follicle Cells; A Novel In Vivo Assay for the Detection of Genotoxic Agents

  • M. T. Goldberg
  • E. A. Goldberg
  • R. Church
  • M. H. Hardy
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 181)


Nuclear aberrations are morphological endpoints visible with light microscopy 24 hours after carcinogen treatment (Wargovich et al., 1983). These endpoints include micronuclei (Heddle, 1973; Schmid, 1973) as well as indicators of apoptosis (Kerr et al., 1972) such as pyknotic or karyorrhectic nuclei and vacuolated nuclear fragments appearing in cells after carcinogenic exposure (see Goldberg et al., 1983).


Hair Follicle Dose Response Curve Acentric Fragment Hair Bulb Human Hair Follicle 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • M. T. Goldberg
    • 1
    • 2
  • E. A. Goldberg
    • 1
  • R. Church
    • 1
  • M. H. Hardy
    • 1
  1. 1.Department of Biomedical SciencesUniversity of GuelphGuelphCanada
  2. 2.International Agency for Research on CancerUnit of Environmental Carcinogens and Host FactorsLyonFrance

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