Skip to main content
SpringerLink
Log in
Book cover

Blood Cells as a Tissue pp 157–177Cite as

Increased Susceptibility to Infection Due to Dysfunction of Granulocytes

  • Chapter

  • 38 Accesses

Abstract

The vital protective role of the granulocyte in the defense against bacterial infection is well established by clinical experience. Of course the consequences of granulocytopenia are far more frequently observed in human disease than are the results of disorders of granulocyte function. Nevertheless, studies of disturbances of granulocyte function and the interaction of granulocytes with the plasma proteins and bacteria are vital subjects of clinical investigation not only because they reveal information concerning enhanced susceptibility to infection, but also because they help to unravel the complexities of granulocyte physiology.

Supported by U.S.P.H.S grant #AM-08173 and a grant from the John A. Hartford Foundation. Dr. Nathan is a recipient of a Career Development Award U.S.P.H.S. AM-35361. Dr. Baehner is an Established Investigator of the American Heart Association.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alper, C. A., Abramson, N., Johnston, R. B., Jr., Jandl, J. H. and Rosen, F. S. Increased susceptibility to infection associated with abnormalities of complement-mediated functions and of the third component of complement (C3) NEJM. In press.

    Google Scholar 

  2. Miller, M.E., Seals, J., Kaye, R., and Levitsky, L. C. A familial plasma-associated defect of phagocytosis. A new cause of recurrent bacterial infection. Lancet 2: 163, 1968.

    Google Scholar 

  3. Miller, M. E. Phagocytosis in the newborn infant: Humoral and cellular factors. J. Pediat. 74: 255, 1969.

    Article  Google Scholar 

  4. Coen, R., Grush, O., and Kauder, E. Studies of bactericidal activity and metabolism of the leukocyte in full-term neonates. J. Pediat. 75: 400, 1969.

    Article  Google Scholar 

  5. Michelle, R. H., Pancake, S. J., Noseworthy, J. and Karnovsky, M. L. Measurements of rates of phagocytosis: The use of cellular monolayers. J. Cell. Biol. 40: 216, 1969.

    Article  Google Scholar 

  6. Singer, J. M., and Van Oss, C. J. Radioiodination of latex particles. J. Reticuloendothel. Soc. 6: 281, 1969.

    Google Scholar 

  7. Baehner, R. L. Personal observation.

    Google Scholar 

  8. Malawista, S. E., and Bodel, D. T. The dissociation by colchicine of phagocytosis from increased oxygen consumption in human leukocytes. J. Clin. Invest. 46: 786, 1967.

    Article  Google Scholar 

  9. Elsbach, D. Increased synthesis of phospholipid during phagocytosis. J. Clin. Invest. 47: 2217, 1968.

    Article  Google Scholar 

  10. Shohet, S. B. Changes in fatty acid metabolism in human leukemic granulocytes during phagocytosis. Submitted to J. Lab. Clin. Med. 1969.

    Google Scholar 

  11. Karnovsky, M. L., and Wallach, D. F. W. The metabolic basis of phagocytosis. III. Incorporation of inorganic phosphate into various classes of phosphatides during phagocytosis. J. Biol. Chem. 236: 1895, 1961.

    Google Scholar 

  12. Klebanoff, S. J. Myeloperoxidase-halide-hydrogen peroxide antibacterial system. J. Bact. 95: 2131, 1968.

    Google Scholar 

  13. Klebanoff, S. J., Clem, W. H., and Luebke, R. G. The peroxidase-thiocyanate-hydrogen peroxide antimicrobial system. Biochim. Biophys. Acta 117: 63, 1966.

    Article  Google Scholar 

  14. Cohn, Z. A. and Hirsch, J. G. The influence of phagocytosis on the intracellular distribution of granule associated components of polymorphonuclear leukocytes. J. Exp. Med. 112: 1015, 1960.

    Article  Google Scholar 

  15. Weissmann,G. The role of lysosomes in inflammation and disease. Ann. Rev. Med. 18: 97, 1967.

    Article  Google Scholar 

  16. Blume, R. S., Bennett, J. M., Yankee, R. A., and Wolff, S. M. Defective granulocyte regulation in Chediak-Higashi syndrome. New Eng. J. Med. 279: 1009, 1968.

    Google Scholar 

  17. Valentine, W. N., and Beck, W. C. Biochemical studies on leukocytes. I. Phosphatase activity in health, leukocytosis, and lyelocytic leukemia. J. Lab. Clin. Med. 38: 39, 1951.

    Google Scholar 

  18. Lewis, S. M., and Dacie, J. Neutrophil (leucocyte) alkaline phosphatase in paroxysmal nocturnal haemoglobinuria. Brit. J. Haemat. 11: 549, 1965.

    Article  Google Scholar 

  19. Sammour, M. B., and Hilal, S. O. Alkaline phosphatase activity of polymorphonuclear leukocytes in relation to oral contraceptives. Amer. J. Obstet. Gynec. 103: 832, 1969.

    Google Scholar 

  20. Lehrer, R. I., and Cline, M. J. Leukocyte myeloperoxidase deficiency and disseminated candidiasis: The role of myeloperoxidase in resistance to Candida infection. J. Clin. Invest. 48: 1478, 1969.

    Article  Google Scholar 

  21. Zeya, H. I., and Spitznagel, J. K. Antimicrobial specificity of leukocyte lysosomal cationic proteins. Science 154: 1049, 1966.

    Article  Google Scholar 

  22. Zeya, H. I., and Spitznagel, J. K. Arginine-rich proteins of polymorphonuclear leukocyte lysosomes: Antimicrobial specificity and biochemical heterogeneity. J. Exp. Med. 127: 927, 1968.

    Article  Google Scholar 

  23. Zucker-Franklin, D., and Hirsch, J. G. Electron microscope studies on the degranulation of rabbit peritoneal leukocytes during phagocytosis. J. Exp. Med. 120: 569, 1964.

    Article  Google Scholar 

  24. Nathan, D. G. Personal communication.

    Google Scholar 

  25. Hirsch, J. G. Cinemicrophotographic observations on granule lysis in polymorphonuclear leucocytes during phagocytosis. J. Exp. Med. 116: 827, 1962.

    Article  Google Scholar 

  26. Weissmann, G. Labilization and stabilization of lysosomes. Fed. Proc. 23: 1038, 1964.

    Google Scholar 

  27. Berendes, H., Bridges, R. A., and Good, R. A. Fatal granulomatosus of childhood: Clinical study of a new syndrome. Minn. Med. 40: 309, 1957.

    Google Scholar 

  28. Janeway, C. A., Craig, J., Davidson, M., Downey, N., Gitlin, D., and Sullivan, J. C. Hypergamma globulinemia associated with severe recurrent and nonspecific infection. Amer. J. Dis. Child. 88: 388, 1954.

    Google Scholar 

  29. Landing, B. H., and Shirkey, H. S. Syndrome of recurrent infection and infiltration of viscera by pigmented lipid histiocytes. Pediatrics 20: 431, 1957.

    Google Scholar 

  30. Carson, M. J., Chadwick, D. L., Brubaker, C. A., Cleland, R. S., and Landing, B. H. Thirteen boys with progressive septic granulomatosis. Pediatrics 35: 405, 1965.

    Google Scholar 

  31. Philippart, A. I., Colodny, A. H., and Baehner, R. L. Chronic granulomatous disease of childhood. J. Pediat. Surg. 4: 85, 1969.

    Article  Google Scholar 

  32. Holmes, B., Quie, P. G., Windhorst, D. B., and Good, R. A. Fatal granulomatous disease of childhood: An inborn abnormality of phagocytic function. Lancet 1: 1225, 1966.

    Article  Google Scholar 

  33. Kaplan, E. L., Laxdal, T., and Quie, P. G. Studies of polymorphonuclear leukocytes from patients with chronic granulo-matous disease of childhood: Bactericidal capacity for streptococci. Pediatrics 41: 591, 1968.

    Google Scholar 

  34. Macfarlane, P. S., Speirs, A. L., and Sommerville, R. G. Fatal granulomatous disease of childhood and benign lymphocytic infiltration of skin: (congenital dysphagocytosis). Lancet 1: 408, 1967.

    Article  Google Scholar 

  35. Davis, W. C., Douglas, S. D., and Fudenberg, H. H. A selective neutrophil dysfunction syndrome: Impaired killing of Staphy- locci. Ann. Intern. Med. 69: 1237, 1968.

    Google Scholar 

  36. Johnston, R. B., Jr., and Baehner, R. L. Improvement of leukocyte bactericidal activity in chronic granulomatous disease. Blood. In press.

    Google Scholar 

  37. Anderson, V., Koch, C., Vejlsgaard, R. and Wilken-Jenses, K. Fatal granulomatous disease. Acta Paediat. Scand. 57: 110, 1968.

    Article  Google Scholar 

  38. Nathan, D. G., Baehner, R. L., and Weaver, D. K. Failure of nitroblue tetrazolium reduction in the phagocytic vacuoles of leukocytes in chronic granulomatous disease. J. Clin. Invest. 48: 1895, 1969.

    Article  Google Scholar 

  39. Quie, P. G., White, J. G., Holmes, B., and Good, R. A. In vitro bactericidal capacity of human polymorphonuclear leukocytes: Diminished activity in chronic granulomatous disease of childhood. J. Clin. Invest. 46: 668, 1967.

    Google Scholar 

  40. Kauder, E., Kahle, L. L., Morene, H., and Partin, J. C. Leukocyte degranulation and vacuole formation in patients with chronic granulomatous disease of childhood. J. Clin. Invest. 47: 1753, 1968.

    Article  Google Scholar 

  41. Elsbach, P., Zucker-Franklin, D., and Sansaricq, C. Increased lecithin synthesis during phagocytosis by normal leukocytes and by leukocytes in chronic granulomatous diseases. New Eng. J. Med. 280: 1319, 1969.

    Article  Google Scholar 

  42. Baehner, R. L., Karnovsky, M. T., and Karnovsky, M. L. De-granulation of leukocytes in chronic granulomatous disease. J. Clin. Invest. 47: 187, 1969.

    Article  Google Scholar 

  43. Mandell, G. L., and Hook, E. W. Leukocyte function in chronic granulomatous disease of childhood. Amer. J. Med. 47: 473, 1969.

    Article  Google Scholar 

  44. Baldridge, C. W., and Gerard, R. W. The extra respiration of phagocytosis. Amer. J. Physiol. 103: 235, 1933.

    Google Scholar 

  45. Sbarra, A. J., and Karnovsky, M. L. Biochemical basis of phagocytosis particles by polymorphonuclear leukocytes. J. Biol. Chem. 234: 1355, 1959.

    Google Scholar 

  46. Iyer, G. Y., Islam, M. F., and Quastel, J. H. Biochemical aspects of phagocytosis. Nature (London) 192: 535, 1961.

    Article  Google Scholar 

  47. Chance, B. On the reaction of catalase peroxides with acceptors. J. Biol. Chem. 182: 649, 1950.

    Google Scholar 

  48. Cagan, R. H., and Karnovsky, M. L. The enzymatic basis of the respiratory stimulation during phagocytosis. Nature (London) 204: 255, 1964.

    Article  Google Scholar 

  49. Zatti, M., and Rossi, F. Mechanism of respiratory stimulation in phagocytozing leukocytes: KCN-insensitive oxidation of NADPH2. Experientia 22: 758, 1966.

    Article  Google Scholar 

  50. Baehner, R. L., Gilman, N. and Karnovsky, M. L. Respiration and glucose oxidation in human and guinea pig leukocytes - comparative studies. J. Clin. Invest. In press.

    Google Scholar 

  51. Holmes, B., and Page, A. R. Metabolic abnormalities of leukocytes from children with CGD. J. Cell. Biol. 31: 48a, 1966.

    Google Scholar 

  52. Baehner, R. L., and Nathan, D. G. Leukocyte oxidase: Defective activity in chronic granulomatous disease. Science 155: 835, 1967.

    Article  Google Scholar 

  53. Holmes, B., Page, A.R., and Good, R. A. Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function. J. Clin. Invest. 46: 1422, 1967.

    Article  Google Scholar 

  54. Baehner, R. L., and Nathan, D. G. Quantitative nitroblue tetrazolium test in chronic granulomatous disease. New Eng. J. Med. 278: 971, 1968.

    Google Scholar 

  55. Baehner, R. L., and Karnovsky, M. L. Deficiency of reduced nicotinamide adenine dinucleotide oxidase in chronic granulo-matous disease. Science 162: 1277, 1968.

    Article  Google Scholar 

  56. Klebanoff, S. J., and White, L. R. Iodinating defect in the leukocytes of a patient with chronic granulomatous disease of childhood. New Eng. J. Med. 280: 460, 1969.

    Google Scholar 

  57. Hirsch, J. G. Further studies on preparation and properties of phagocytin. J. Exp. Med. 111: 323, 1969.

    Google Scholar 

  58. Skarnes, R. C., and Watson, D. W. Antimicrobial factors of normal tissues and fluids. Bact. Rev. 21: 273, 1957.

    Google Scholar 

  59. Baehner, R. L., Karnovsky, M. T., and Nathan, D. G. Correction of metabolic deficiencies in chronic granulomatous disease. J. Clin. Invest. In press.

    Google Scholar 

  60. Mandell, G. L., Rubin, W., and Hook, E. W. Alteration of bactericidal activity of polymorphonuclear neutrophils by a NAHH oxidase inhibitor. J. Clin. Invest. 48: 55a, 1969 (abstract)

    Google Scholar 

  61. Quie, P. G., Kaplan, E. L., Page, A. R., Grusky, F. L., and Malawista, S. F. Defective polymorphonuclear leukocyte function and chronic granulomatous disease in two female children. New Eng. J. Med. 278: 976, 1968.

    Article  Google Scholar 

  62. Azimi, P., Bodenbender, J. G., Hintz, R. L., and Kontras, S. B. Chronic granulomatous disease in three sisters. Lancet 1: 208, 1968.

    Article  Google Scholar 

  63. Chandra, R. K., Cope, W. A., and Soothill, J. F. Chronic granulomatous disease. Evidence for an autosomal mode of inheritance. Lancet 2: 71, 1969.

    Article  Google Scholar 

  64. Windhorst, D. B., Holmes, B., and Good, R. A. Newly defined X-linked trait in man with demonstration of Lyon effect in carrier females. Lancet 1: 737, 1967.

    Article  Google Scholar 

  65. Windhorst, D. B. Inheritance of chronic granulomatous disease. Lancet 2: 543, 1969.

    Article  Google Scholar 

  66. Edwards, J. H. Inheritance of chronic granulomatous disease. Lancet 2: 850, 1969.

    Article  Google Scholar 

  67. Douglas, S. D., Davis, W. C., and Fudenberg, H. H. Inheritance of chronic granulomatous disease. Lancet 2: 851, 1969.

    Google Scholar 

  68. Windhorst, D. B., Holmes, B. and Good, R. A. A newly defined X-linked trait in man with demonstration of the Lyon effect in carrier females. Lancet 1: 737, 1967.

    Article  Google Scholar 

  69. Davis, W. C., Douglas, S. D., and Fudenberg, H. H. A selective neutrophil dysfunction syndrome: Impaired killing of Staphylococci. Ann. Intern. Med. 69: 1237, 1968.

    Google Scholar 

  70. Good, R. A., Quie, P. G., Windhorst, D. B., Page, A. R., Roddy, G. E., White, J., Wolfson, J. J., and Holmes, B. Fatal (chronic) granulomatous disease of childhood: A hereditary defect of leukocyte function. Seminars Hemat. 5: 215, 1968.

    Google Scholar 

  71. Pearse, A. G. E. Histochemistry, theoretical and applied. Second Edition. Little,Brown and Co., Boston 1960, p. 538.

    Google Scholar 

  72. Baehner, R. L. Personal communication.

    Google Scholar 

  73. Karnovsky, M. L. Metabolic basis of phagocytic activity. Physiol. Rev. 42: 143, 1962.

    Google Scholar 

  74. Rossi, F., and Zatti, M. Biochemical aspects of phagocytosis in polymorphonuclear leukocytes. NADH and NADPH oxidation by the granules of resting and phagocytizing cells. Experientia 20: 21, 1964.

    Article  Google Scholar 

  75. Douglas, S. D., Davis, W. C., and Fudenberg, H. H. Granulocytopathies: Pleomorphism of neutrophil dysfunction. Amer. J. Med. 46: 901, 1969.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Hematology of the Department of Medicine Children’s Hospital Medical Center, Department of Pediatrics, Harvard Medical School, Boston, Mass., 02115, USA

    David G. Nathan & Robert L. Baehner

Authors
  1. David G. Nathan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert L. Baehner
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Research, The Lankenau Hospital, Philadelphia, Pennsylvania, USA

    William L. Holmes (Director) (Director)

Rights and permissions

Reprints and permissions

Copyright information

© 1970 Plenum Press, New York

About this chapter

Cite this chapter

Nathan, D.G., Baehner, R.L. (1970). Increased Susceptibility to Infection Due to Dysfunction of Granulocytes. In: Holmes, W.L. (eds) Blood Cells as a Tissue. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7873-0_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-7873-0_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7875-4

  • Online ISBN: 978-1-4684-7873-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation