Increased Susceptibility to Infection Due to Dysfunction of Granulocytes

  • David G. Nathan
  • Robert L. Baehner


The vital protective role of the granulocyte in the defense against bacterial infection is well established by clinical experience. Of course the consequences of granulocytopenia are far more frequently observed in human disease than are the results of disorders of granulocyte function. Nevertheless, studies of disturbances of granulocyte function and the interaction of granulocytes with the plasma proteins and bacteria are vital subjects of clinical investigation not only because they reveal information concerning enhanced susceptibility to infection, but also because they help to unravel the complexities of granulocyte physiology.


Respiratory Burst Chronic Granulomatous Disease NADH Oxidase Chronic Granulomatous Disease Patient Latex Spherule 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • David G. Nathan
    • 1
  • Robert L. Baehner
    • 1
  1. 1.Division of Hematology of the Department of Medicine Children’s Hospital Medical Center, Department of PediatricsHarvard Medical SchoolBostonUSA

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