Megakaryocyte and Platelet Development and Regulation

  • T. T. OdellJr.
  • C. W. Jackson


Wright (1), in 1906, first reported that blood platelets arise by fragmentation of the cytoplasm of megakaryocytes. It was not, however, until many years later that this view was universally accepted. Immunologic (2,3,4) and cytochemical (5) studies, as well as time-lapse photography of megakaryocytes in bone marrow cultures (6,7,8) and in vivo (9), have more recently supplied convincing evidence of the origin of platelets from megakaryocytes.


Ploidy Level Generation Cycle Blood Platelet Cell Generation Cycle Platelet Production 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • T. T. OdellJr.
    • 1
  • C. W. Jackson
    • 1
  1. 1.Biology DivisionOak Ridge National LaboratoryOak RidgeUSA

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