Present Status of Blood Component Therapy

  • J. L. Tullis


It is not possible for me to begin my presentation without pausing momentarily to honor the memory of the physician and scientist who would have preceded me on this program but for an abrupt and untimely death earlier this month. It is paradoxical that I delivered the eulogy at his funeral just a fortnight ago, and now once again follow his footsteps on a program that particularly illuminates his decades of interest in the lymphoproliferative disorders. I was not a student of Bill Dameshek, and I never even collaborated with him on a scientific paper. But I always cherished his provocative nature and the blithe spirit of his imaginative mind — even to the coining of such illegitimate words as immunocyte — to categorize a type of stimulated lymphocyte — which gave off an aura of globulin synthesis. It is never possible to refer to someone as great or possessing of genius when one is a contemporary. Rather, such appellations are pounded out in the hard mill of history. But to me, Dr. Dameshek was a unique person. He was warm. He was compassionate. He was a born teacher. He could inspire others to achieve heights greater than themselves. Most of all, I remember him, not for his specific deeds or any single scientific paper, but rather for the broad brush of his personality as a physician, an editor, and an investigator. He was a Twentieth Century version of the Seventeenth Century natural philosopher.


White Cell Buffy Coat Gamma Globulin Barium Sulfate Oxyhemoglobin Dissociation Curve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Tullis, J. L., Driscoll, S., Ketchel, M. M., Brown, I. W., Jr., Tinch, R. J., Principles involved in Glycerolization and Deglycerolization of Red Cells using Cohn Fractionator, CONFERENCE ON THE PLASMA PROTEINS AND CELLULAR ELEMENTS OF THE BLOOD, Cambridge, Massachusetts, November 15, 1954, p. 17.Google Scholar
  2. 2.
    Tullis, J. L., Surgenor, D. M., Tinch, R. J., D’Hont, N., Gilchrist, F., Driscoll, S., Batchelor, W. H., New Principle of Closed System Centrifugation, SCIENCE 124: 792, 1956.CrossRefGoogle Scholar
  3. 3.
    Ketchel, M. M., Tullis, J. L., Gibson, J. G. II, Tinch, R. J. and Driscoll, The Preservation of Erythrocytes at Freezing Temperatures, PROC. VI CONG. INT. SOC. BLOOD TRANSF. 7: 320, 1958.Google Scholar
  4. 4.
    Tullis, J. L., Ketchel, M. M., Pyle, H. M., Pennell, R. B., Gibson, J. G. II, Tinch, R. J., Driscoll, S., Studies on the In-vivo Survival of Glycerolized and Frozen Human Red Blood Cells, JAMA 168: 399, 1958.CrossRefGoogle Scholar
  5. 5.
    Ketchel, M. M., Tullis, J. L., Tinch, R. J., Driscoll, S., Surgenor, D. M., Use of Biomechanical Equipment for the Long-Term Preservation of Erythrocytes, JAMA 168: 404, 1958.CrossRefGoogle Scholar
  6. 6.
    Tullis, J. L., Clinical Use of Frozen Red Cells, ARCH. SURG. 81: 151, 1960.Google Scholar
  7. 7.
    Haynes, L., Tullis, J. L., Pyle, H. M., Wallach, S., Sproul, M. T., Clinical Use of Glycerolized Frozen Blood, JANA 173: 1657, 1960.Google Scholar
  8. 8.
    O’Brien, T. G., Haynes, L. L., Hering, A. C., Tullis, J. L., Watkins, E., Jr., The Use of Glycerolized Frozen Blood in Vascular Surgery and Extracorporeal Circulation, SURGERY (St. Louis) 49: 109, 1961.Google Scholar
  9. 9.
    Wallach, S.,Zemp, J. W., Cavins, J. A., Jenkins, L. J., Jr., Bethea, M., Freshette, L., Haynes, L. L. and Tullis, J. L., Cation Flux and Electrolyte Composition of Frozen-Deglycerolized Blood, BLOOD 20: 344, 1962.Google Scholar
  10. 10.
    Tullis, J. L., Editorial - Present Status of Blood Freezing, TRANSFUSION 3: 155, 1963.CrossRefGoogle Scholar
  11. 11.
    Tullis, J. L., Red Cell Storage in the Frozen State in “The Red Blood Cell,” Academic Press, Inc., New York, 1964, p. 491.Google Scholar
  12. 12.
    Tullis, J. L., Slow Freezing of Red Cells, PROC. X CONG. INT. SOC. BLOOD TRANSF. 23: 627, 1965.Google Scholar
  13. 13.
    Tullis, J. L., Gibson, J. G. II, Sproul, M.T., Tinch, R. J. and Baudanza, P., Advantages of the High Glycerol Mechanical Systems for Red Cell Preservation; A 10-year Study of Stability and Yield, International Symposium on Modern Problems of Blood Preservation, March 17–18, 1969, Frankfurt, Germany, (G. Fischer Verlag, Stuttgart - publishers, in press).Google Scholar
  14. 14.
    Tullis, J. L., Tinch, R. J., Gibson, J. G. II and Baudanza, P., A Simplified Centrifuge for the Separation and Processing of Blood Cells, TRANSFUSION 7: 232, 1967.Google Scholar
  15. 15.
    Aster, R.H. and Jandl, J. H., Platelet Sequestration in Man. I. Methods, J. CLIN. INVEST. 43: 843, 1964.CrossRefGoogle Scholar
  16. 16.
    Murphy, S. and Gardner, F., Platelet Preservation. Effect of Storage Temperature on Maintenance of Platelet Viability. Deleterious Effect of Refrigerated Storage, NEJM 280; 1094, 1969.CrossRefGoogle Scholar
  17. 17.
    Miller, W. V. (personal communication).Google Scholar
  18. 18.
    Tullis, J. L., Eberle, W. G. II, Baudanza, P. and Tinch, R. J., Platelet-pheresis - Description of a New Technic, TRANSFUSION 8: 154, 1968.CrossRefGoogle Scholar
  19. 19.
    Tullis, J. L. and Tinch, R. J., Separation of Leukocytes and Platelets, Symposium of the Formed Elements - The Protein, Carbohydrate, Lipid, Steroid, Peptide and Other Components of Plasma, July 11, 1950, PROC. UNIV. LAB. PHYS. CHEM. RELATED TO MED. AND PUBLIC HEALTH, HARVARD UNIVERSITY, 1951, p. 66.Google Scholar
  20. 20.
    Yankee, R. A., Freireich, E. J., Carbone, P. P. and Frei, E., Replacement Therapy Using Normal and Chronic Myelogenous Leukemic Leukocytes, BLOOD 24: 844, 1964.Google Scholar
  21. 21.
    Kauder, E., Boggs, D. R., Athens, J. W., Vodopick, H.A., Cartwright, G. E. and Wintrobe, M. M., Leukokinetic Studies. XII. Kinetic Studies of Normal Isologous Neutrophilic Granulocytes Transfused into Normal Subjects, SUC. EXPER. BIOL. AND MED. 120: 595, 1965.Google Scholar
  22. 22.
    Buckner, D., Eisel, R. and terry, S., Blood Cell Separation in the Dog by Continuous Flow Centrifugation, BLOOD 31: 653, 1968.Google Scholar
  23. 23.
    Buckner, D., Graw, R. G., Jr Eisel, R. J., Hen- derson, E. S. and Perry, S., Leukapheresis by Continuous Flow Centrifugation (CFC) in Patients with Chronic Myelocytic Leukemia (CML), BLOOD 33: 353, 1969.Google Scholar
  24. 24.
    Cavins, J. A., Djerassi, I., Roy, A. J., and Klein, E., Preservation of Viable Human Granulocytes at Low Temperatures in Dimethylsulfoxide, CRYOBIOLOGY 2: 129, 1965.CrossRefGoogle Scholar
  25. 25.
    Bouroncle, B. A., Preservation of Human Normal and Leukemia Cells with Dimethylsulfoxide at -800C., CRYOBIOLOGY 3: 445, 1967.CrossRefGoogle Scholar
  26. 26.
    Perry, S., Leukocyte Kinetics in Man, MED. ANN. DIST. COLUMBIA 38: 10, 1969.Google Scholar
  27. 27.
    Hinman, J., Tullis, J. L., Saravis, C. A. and Pennell, R. B., Intravenous Use of Plasmin Treated Immunoglobulin G. 1. Preliminary Report on Tolerance by Immunologically Deficient Patients, VOX SANG. 13: 85, 1967.Google Scholar
  28. 28.
    Hinman, J. and Tullis, J. L., Dissociated Gamma Globulin in Intravenous Treatment of Infection, VOX SANG. 17: 75, 1969.Google Scholar
  29. 29.
    Merler, E., Rosen, F. S., Salmon, 5., Crain, J. D. and Janeway, C., studies with Intravenous Gamma Globulin, VOX SANG. 13: 103, 1967.Google Scholar
  30. 30.
    Seegers, W. H., Chemistry of Prothrombin and Thrombin, IV INT. CONG. BIOCHEM., Vienna, Austria, 1958.Google Scholar
  31. 31.
    McMillan, C. W., Tullis, J. L., Diamond, L. K., Clinical Studies with Barium Sulfate Eluate, VOX SANG. 7: 96, 1962.CrossRefGoogle Scholar
  32. 32.
    Soulier, J. P., Treatment of Hemophilia A and B, PROC. X CONG. INT. SOC. BLOOD TRANSF. 23: 1313, 1965.Google Scholar
  33. 33.
    Melin, M., Pennell, R. B., Tullis, J. L., Baudanza, P., DiFrancesco, A., Jansky, J. W., Studies in the Chromatography of Trace Constituents of Human Plasma. I. A Crude Prothrombin-Containing Fraction, PROC. X CONG. INT. SOC. BLOOD TRANSF. 23: 1228, 1965.Google Scholar
  34. 34.
    Tullis, J. L., Melin, M. and Jurigian, P., Clinical Use of Human Prothrombin Complexes, NEJM 273: 667, 1965.CrossRefGoogle Scholar
  35. 35.
    Breen, F. A., Jr. and Tullis, J. L., Prothrombin Concentrates in Treatment of Christmas Disease and Allied Disorders, JANA 208: 1848, 1969.Google Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • J. L. Tullis
    • 1
  1. 1.Department of Medicine, Deaconess HospitalBlood Research Institute, Inc.BostonUSA

Personalised recommendations