Lymphoproliferative Disorders: Recent Concepts and Implications for Therapy

  • Arnold D. Rubin


The treatment of chronic lymphocytic leukemia (CLL), lymphoma and Hodgkin’s disease has been the subject of several recent detailed treatises (1–3). These relatively optimistic reports describe a variety of effective new chemotherapeutic agents and emphasize a concept that radiotherapy can potentially cure some forms of lymphoma (4–6). Furthermore, intelligent administration of therapeutic modalities has been facilitated by the introduction of additional diagnostic techniques, such as lymphangiography, which aid in the precise localization of lymphoid tumors. Finally, re-evaluation of the histologic classification of various forms of lymphomas had led to a more clear understanding of natural history and of how the course of the disease might be altered by specific therapy (7). Although empirical in nature, the information derived from these studies has been extremely helpful to the clinician. Meanwhile, recent advances in basic immunobiology, focussing on the lymphoid system as a functional unit, have uncovered some important facts regarding the biological significance of lymphoid cell proliferation. Most likely, decisive therapy of lymphoproliferative disorders will ultimately depend on the application of basic knowledge of lymphoid physiology. The present report will attempt to utilize our present knowledge of the functioning lymphoid system in a search for possible sources of malfunction and their therapeutic implications.


Chronic Lymphocytic Leukemia Lymphoproliferative Disorder Reticulum Cell Autoimmune Hemolytic Anemia Small Lymphocyte 


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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Arnold D. Rubin
    • 1
  1. 1.The Mount Sinai School of MedicineNew YorkUSA

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