An Evaluation of the Present Status of Neutrophil Replacement Therapy
The replacement of shed blood by transfusion of stored, whole blood became practical over 25 years ago and has been widely used ever since. However, it has gradually become evident that in many clinical disorders only one specific component of blood is needed; e.g., erythrocytes in some of the anemias, plasma in burned patients, gamma globulin in agammaglobulinemics, etc. It also has become evident that the administration of unneeded blood components may be undesirable. Illustrative examples are the transfusion reactions due to leukocyte incompatibility, or even more serious, the high incidence of post-transfusion hepatitis due to virus particles transmitted in the often unneeded plasma.
KeywordsTransfusion Reaction Allogeneic Transfusion Granulocyte Transfusion Blood Granulocyte Marginal Site
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