An Evaluation of the Present Status of Neutrophil Replacement Therapy

  • John W. Athens


The replacement of shed blood by transfusion of stored, whole blood became practical over 25 years ago and has been widely used ever since. However, it has gradually become evident that in many clinical disorders only one specific component of blood is needed; e.g., erythrocytes in some of the anemias, plasma in burned patients, gamma globulin in agammaglobulinemics, etc. It also has become evident that the administration of unneeded blood components may be undesirable. Illustrative examples are the transfusion reactions due to leukocyte incompatibility, or even more serious, the high incidence of post-transfusion hepatitis due to virus particles transmitted in the often unneeded plasma.


Transfusion Reaction Allogeneic Transfusion Granulocyte Transfusion Blood Granulocyte Marginal Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    J.W. Athens, H. Ashenbrucker, G.E. Cartwright, and M.M. Wintrobe. Leukokinetic studies: II. A method for labeling granulocytes in vitro with radioactive diisopropylfluorophosphate (DFP32). J. Clin. Invest., 39: 1481, 1960.CrossRefGoogle Scholar
  2. 2.
    J.W. Athens, O.P. Haab, S.O. Raab, A.M. Mauer, H. Ashenbrucker, G.E. Cartwright and M.M. Wintrobe. Leukokinetic studies: IV. The total blood, circulating and marginal granulocyte pools and the granulocyte turnover rate in normal subjects. J. Clin. Invest., 40: 989, 1961.CrossRefGoogle Scholar
  3. 3.
    J.W. Athens, S.O. Raab, O.P. Haab, A.M. Mauer, H. Ashenbrucker, G.E. Cartwright and M.M. Wintrobe. Leukokinetic studies: III. The distribution of granulocytes in the blood of normal subjects. J. Clin. Invest., 40: 159, 1961.CrossRefGoogle Scholar
  4. 4.
    E. Kauder, D.R. Boggs, J.W. Athens, H.A. Vodopick, G.E. Cartwright and M.M. Wintrobe. Leukokinetic studies: XII. Kinetic studies of normal isologous neutrophilic granulocytes transfused into normal subjects. Proc. Soc. Exper. Biol. and Med., 120: 595, 1965.Google Scholar
  5. 5.
    J.W. Athens, D.R. Boggs, G.E. Cartwright and M.M. Wintrobe. An evaluation of granulocyte transfusions. Haematologica Latina 10: 109–115, 1967.Google Scholar
  6. 6.
    D.R. Boggs, J.W. Athens, O.P. Haab, S.O. Raab, G.E. Cartwright and M.M. Wintrobe. Leukokinetic studies: VIII. A search for an extramedullary tissue pool of neutrophilic granulocytes. Proc. Sox. Exper. Biol. and Med., 115: 792, 1964.Google Scholar
  7. 7.
    E.J. Freireich, G. Judson and R.H. Levin. Separation and collection of leukocytes. Cancer Research 25: 1516–1520, 1965.Google Scholar
  8. 8.
    E.J. Freireich. Leukocyte collection by an in vivo continuous flow centrifuge. J’ Clin.,Invest. 47: 36a, 1968.Google Scholar
  9. 9.
    E.J. Freireich. Continuous flow in vivo blood cell separator. Laboratory Management, April, 1968, p. 20–48.Google Scholar
  10. 10.
    J.L. Tullis, R.J. Tinch, J.G. Gibson, P. Baudanza. A simplified centrifuge for the separation and processing of blood. Transfusion 7: 232, 1967.Google Scholar
  11. 11.
    T.J. Greenwalt and S. Perry. Preservation and utilization of the components of human blood. Prog. in Hematol. VI., Spring, 1969, p. 148–180.Google Scholar
  12. 12.
    R.A. Yankee, E.J. Freireich, P.P. Carbone, and E. Frei. Replacement therapy using normal and chronic myelogenous leukemic leukocytes. III. Blood 24: 844, 1964.Google Scholar
  13. 13.
    J.L. Tullis, Personal communication.Google Scholar
  14. 14.
    E.E. Morse, E.J. Freireich, P.P. Carbone, W. Bronsen and E. Frei. The transfusion of leukocytes from donors with chronic myelocytic leukemia to patients with leukopenia. Transfusion 6: 183, 1966.CrossRefGoogle Scholar
  15. 15.
    L. Schwarzenberg, G. Mathe, J.L. Amiel, A. Carlton, M. Schneider and J.R. Schlumberger. Study of factors determining the usefulness and complications of leukocyte transfusions. Am. J. Med. 43: 206, 1967.CrossRefGoogle Scholar
  16. 16.
    D. Buckner, R. Eisel and S. Perry. Blood cell separation in the dog by continuous flow centrifugation. Blood 31: 653, May, 1968.Google Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • John W. Athens
    • 1
  1. 1.Department of MedicineUniversity of Utah College of MedicineSalt Lake CityUSA

Personalised recommendations