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The Therapeutic Possibilities in the Hemoglobinopathies

  • D. J. Weatherall

Abstract

In recent years there has been a rapid increase in knowledge about the structure and function of the hemoglobin molecule in health and disease. Many genetic disorders of hemoglobin synthesis have been described and the molecular basis of the associated clinical pictures elucidated. Unfortunately none of these advances have led to an improvement in the clinical management of affected patients.

Keywords

Exchange Transfusion Globin Chain Hypochromic Anemia Hemoglobin Molecule Total Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ingram, V. M., Stretton, A. O. W. (1959) ‘Genetic basis of the thalassaemia diseases.’ Nature, 184, 1903–1909.CrossRefGoogle Scholar
  2. 2.
    Clegg, J. B., Weatherall, D. J., Na-Nakorn, S., and Wasi, P. (1968) ‘Haemoglobin synthesis in ß-thalassaemia’ Nature, 220, 664Google Scholar
  3. 3.
    Wasi, P., Na-Nakorn, S. and Suingdumrong, A. (1964) ‘Haemoglobin H disease in Thailand: a genetical study.’ Nature, 204, 907Google Scholar
  4. 4.
    Na-Nakorn, S.,Wasi, P., Pornpatkul, M. and Pootrakul,S. (1969) ‘The genetic basis of haemoglobin H disease from newborn offspring of patients.’ Nature, 223, 59Google Scholar
  5. 5.
    Weatherall, D. J., Clegg, J. B. and Wong Hock Boon (1969) ‘The haemoglobin constitution of infants with the haemoglobin Bart’s hydrops foetalis syndrome.’ Brit. J. Haemat., In press.Google Scholar
  6. 6.
    Bargellesi, A., Pontremoli, S., Menini, C. and Conconi, F. (1968) ‘Excess of alpha globin synthesis in homozygous beta-thalassemia and its removal from the red blood cell cytoplasm.’ European. J. Biochem., 2, 364CrossRefGoogle Scholar
  7. 7.
    Weatherall, D. J., Clegg, J. B., Na-Nakorn, S. and Wasi, P. (1969). ‘The pattern of disordered haemoglobin synthesis in homozygous and heterozygous ß-thalassaemia’ Brit. J. Haemat., 16, 251.CrossRefGoogle Scholar
  8. 8.
    Sephton-Smith, R. (1964) ‘Chelating agents in the diagnosis and treatment of iron overload in thalassemiâ’:. Anns. New York Acad. Sci., 119, 776CrossRefGoogle Scholar
  9. 9.
    Hall, J. G. and Motulsky, A, G. ‘Production of foetal haemoglobin in marrow culture of adult blood.’ Nature, 217, 569–571.Google Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • D. J. Weatherall
    • 1
  1. 1.Department of Medicine, Nuffield Unit of Medical GeneticsUniversity of LiverpoolLiverpoolUK

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