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Small Vessel Compliance May Explain Peripheral Pressure-Flow Relations

  • Nico Westerhof
  • Rob Braakman
  • Pieter Sipkema
Part of the NATO ASI Series book series (volume 166)

Abstract

The load on the heart is formed by the hydraulic input impedance of the arterial system. The three main factors contributing to this load are peripheral resistance, which is mainly located in the periphery, (total) arterial compliance, which is mainly located in the large conduit arteries (the ascending aorta accounts for about 50% of the compliance), and (ascending aortic) characteristic impedance which accounts for blood mass and compliance of the proximal aorta (Westerhof et al., 1971). The effect of blood viscosity on these last two factors is so small that the contribution of (Poiseuille) resistance to flow may be disregarded. In other words, the total arterial compliance and the aortic characteristic impedance are mainly determined by the compliant properties of the vessels and the mass of blood. The peripheral bed, however, not only acts as a resistor but consists of a network of compliant vessels. From the viewpoint of an oscillatory load on the heart the compliance of the periphery may not directly play an important role. When the isolated (cat) heart was made to pump into a three element windkessel model of the cat’s arterial tree, where only total arterial compliance of the large vessels was accounted for, the resulting pressure and flow wave forms were close to in-vivo patterns (Elzinga and Westerhof, 1973). However, there exist a number of methods to determine total arterial compliance. Not all of these methods lead to the same value of compliance (Randall et al., 1984; Yin et al.; 1987, Toorop et al., 1987) as discussed by Yin in this volume (Yin et al., 1988). The compliance of the periphery (Morgenstern et al., 1973; Spaan et al., 1981) does play a role in peripheral pressure-flow relations since even small changes in lumen result in rather large changes in resistance. The relationship between compliance (pressure-volume relation) and resistance (pressure-flow relation) in the small vessels is the subject of this review. The pressure-volume relation is not a linear one so that compliance, the slope of the relation, is pressure dependent.

Keywords

Peripheral Resistance Extensor Digitorum Longus Muscle Steady State Pressure Maximal Vasodilation Total Arterial Compliance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Baez, S., 1961, Response characteristics of perfused microvessels, Angiology, 12: 452.PubMedCrossRefGoogle Scholar
  2. Bellamy, R.F., 1978, Diastolic coronary artery pressure flow relations in the dog, Circ. Res., 43: 92.PubMedCrossRefGoogle Scholar
  3. Braakman, R. Pressure-flow relationships in skeletal muscle. Ph. D. Dissertation Free University of Amsterdam, 1988.Google Scholar
  4. Cox, R.H.,1976, Effects of norepinephrine on mechanics of arteries in vivo, Am. J. Physiol., 231: 420.Google Scholar
  5. Dick, D.E., Kendrick, J.E., Matson, G.L., and Rideout, V.C., 1968, Measurement of nonlinearity in the arterial system of the dog by a new method, Circ. Res., 22: 101.PubMedCrossRefGoogle Scholar
  6. Downey, J.M., 1981, Letter to the Editor, Circ. Res., 48: 299.PubMedCrossRefGoogle Scholar
  7. Elzinga, G., and Westerhof, N., 1973, Pressure and flow generated by the left ventricle against different impedances, Circ. Res., 32: 178.PubMedCrossRefGoogle Scholar
  8. Ehrlich, W., Baer, R.W., Bellamy, R.F., and Randazzo, R., 1980, Instantaneous femoral artery pressure-flow relations in supine anesthetized dogs and the effect of unilateral elevation of femoral venous pressure, Circ. Res., 47: 88.PubMedCrossRefGoogle Scholar
  9. Jones, R.D, and Berne, R.M., 1986, Autoregulation: factors affecting vascular resistance in isolated, perfused skeletal muscle. in: “Circulation in skeletal muscle,” O. Hudlicka, ed., Pergamon Press, London.Google Scholar
  10. Kajiya, F., Tsujioka, K., Goto, M., Wada, Y., Chen, X-L., Nakai,M. Tadaoka, S., Hiramatsu, O., Ogasawara, Y., Mito, K., and Tomonaga, G.,1986, Functional characteristics of intramyocardial capacitance vessels during diastole in the dog, Circ. Res., 58: 476.Google Scholar
  11. Latham, R.D., 1988, Pulse propagation in the systemic arterial tree, in: “Vascular Dynamics,” N. Westerhof, and D.R. Gross, eds., Plenum Press, New York, N.Y.Google Scholar
  12. Morgenstern, C., Hoijes, U., Arnold, G., and Lochner, W., 1973, The influence of coronary pressure and coronary flow on intracoronary blood volume and geometry of the left ventricle, Pfluegers Arch., 340: 101.CrossRefGoogle Scholar
  13. Patel, D.J., Coleman, B.R., Tearney, R.J., Cothran, L.N., and Curry, C.L., 1988, Peripheral Vascular Compliance, in: “Vascular Dynamics,” N. Westerhof, and D.R. Gross, eds., Plenum Press, New York, N.Y.Google Scholar
  14. Randall, O.S., van den Bos, G.C., and Westerhof, N., 1984, Systemic compliance: does it play a role in the genesis of essential hypertension?, Cardiovasc. Res., 18: 455.PubMedCrossRefGoogle Scholar
  15. Smiesko, V., 1971, Unidirectional rate sensitivity component in local control of vascular tone, Pfluegers Arch., 327: 324.CrossRefGoogle Scholar
  16. Spaan, J.A.E., Breuls, N.P.W., and Laird, J.D., 1981, Diastolic-systolic coronary flow differences are caused by intramyocardial pump action in the anesthetized dog, Circ. Res., 49: 584.PubMedCrossRefGoogle Scholar
  17. Toorop, G.P., Westerhof, N., and Elzinga, G., 1987, Beat-to-beat estimation of peripheral resistance and arterial compliance during pressure transients, Am. J. Physiol., 252:H 1275.Google Scholar
  18. Van Huis, G.A., Sipkema, P., and Westerhof, N., 1985, Instantaneous and steady-state pressure-flow relations of the coronary system in the canine beating heart, Cardiovasc. Res., 19: 121.PubMedCrossRefGoogle Scholar
  19. Westerhof, N., Elzinga, G., and Sipkema, P., 1971, An artificial arterial system for pumping hearts J. Appl. Physiol., 31: 776.PubMedGoogle Scholar
  20. Westerhof, N., Sipkema, P., Elzinga, G., Murgo, J.P., and Giolma, J.P., 1979, Arterial impedance, in: “Quantitative Cardiovascular Studies,” N.H.C. Hwang, D.R. Gross, and D.J. Patel, eds., University Park Press, Baltimore, Md., pp. 151.Google Scholar
  21. Yin, F.C.P., Liu, Z., and Brin, K.P., 1987, Estimation of arterial compliance, in: “Ventricular/Vascular coupling,” F.C.P. Yin, ed., Springer Verlag, New York/ Berlin.CrossRefGoogle Scholar
  22. Yin, F.C.P., and Liu, Z., 1988, Arterial compliance-physiological viewpoint, in: “Vascular Dynamics,” N. Westerhof, and D.R. Gross, eds., Plenum Press, New York, N.Y.Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Nico Westerhof
    • 1
  • Rob Braakman
    • 1
  • Pieter Sipkema
    • 1
  1. 1.Lab. for PhysiologyFree University of AmsterdamThe Netherlands

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