Compliance and Aging

  • David R. Gross
Part of the NATO ASI Series book series (volume 166)


It is well-documented that arterial stiffness increases with age (Roy, 1880; Hallock and Benson, 1937; Hass, 1942; Butcher and Newton, 1958; Roach and Burton, 1959; Learoyd and Taylor, 1966; Bader, 1967; Nakashima and Tanikawa, 1971; Mozersky et al., 1973; Gozna et al., 1974; Mirsky and Janz, 1976; Cox, 1977; Newman and Lallemand, 1978; Langewouters, 1982; Yin, Spurgeon and Kallman, 1983). Richter and Mittermayer (1984) reported that the volume of the postmortem human aorta is 35 ml at age 20 years, while at 70 years the volume increases to an average of 111 ml. With age the vessel becomes dilated and stiffens (Learoyd and Taylor, 1966; Nichols et al., 1985). There seems to be little doubt that arteriosclerosis, a frequent complicating aspect of the aging process in modern life, results in severe stiffening of the thoracic aorta, as well as other, more peripheral, vessels. The role that atherosclerosis plays in arterial stiffening has not been well defined.


Pulse Wave Velocity Thoracic Aorta Aortic Segment Human Aorta Ascend Aortic 
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  1. Apter, J.T., Rabinowitz, M. and Cummings, D.H., 1966, Correlation of viscoelastic properties of large arteries with microscopic structure. I. Collagen, elastin and muscle determined chemically, histologically, and physiologically, Circ. Res., 19: 104.CrossRefGoogle Scholar
  2. Avolio, A.P., Chen, S., Wang, R., Zhang, C., Li, M. and O’Rourke, M.F., 1983, Effects of aging on changing arterial compliance and left ventricular load in a northern chinese urban community, Circulation, 68: 50.PubMedCrossRefGoogle Scholar
  3. Avolio, A.P., Deng, F.D., Li, W., Lou, Y., Huang, Z., Xing, L. and O’Rourke, M.F., 1984, Effects of aging on arterial distensibility in populations with high and low prevelance of hypertension: comparison between urban and rural communities in China. Circulation, 71: 207.Google Scholar
  4. Baan, J., van der Velde, E.T., de Bruin, H.G. and Karsdon, J., 1987, Control of the end-systolic pressure-volume relation, in: “Simulation and control of the cardiac system,”: S. Sideman and R. Beyar, eds., CRC press, Boca Raton, Fl., pp 163.Google Scholar
  5. Bader, H., 1967, Dependence of wall stress in human thoracic aorta on age and pressure, Circ. Res., 20: 354.PubMedCrossRefGoogle Scholar
  6. Bramwell, J.C. and Hill, A.V., 1922, The velocity of the pulse wave in man, Proc. Roy. Soc. Lond (Biol.), 93: 298.CrossRefGoogle Scholar
  7. Bramwell, J.C., Hill, A.V. and McSwiney, B.A., 1923, The velocity of the pulse wave in man in relation to age as studied by the hot-wire sphygmograph, Heart, 10: 233.Google Scholar
  8. Butcher, H.B. and Newton, W.T., 1958, The influence of age, arteriosclerosis and homotransplantation upon the elastic properties of major human arteries, Ann. Surg., 148: 1.PubMedCrossRefGoogle Scholar
  9. Cleary, E., 1963, “A correlative and comparative study of the nonuniform arterial wall,” M.D. Thesis, University of Sidney.Google Scholar
  10. Cotton, R. and Wartman, W.B., 1961, Endothelial patterns, in human arteries, their relationship to age, vessel site, and atherosclerosis, Arch. Pathol., 2: 15.Google Scholar
  11. Cox, R.H., 1977, Effects of age on the mechanical properties of rat carotid artery, Am. J. Physiol., 233: H256.PubMedGoogle Scholar
  12. Eliakim, M., Sapozinikov, D. and Weinman, J., 1971, Pulse wave velocity in healthy subjects and in patients with various disease states. Am. Heart J., 82: 448.PubMedCrossRefGoogle Scholar
  13. Faber, M. and Moller-Hou, G., 1952, The human aorta. V. Collagen and elastin in the normal and hypertensive aorta, Acta Pathol. Microbiol. Scand., 31: 377.PubMedCrossRefGoogle Scholar
  14. Fischer, G.M. and Llaurado, J.G., 1966, Collagen and elastin content in canine arteries selected from functionally different vascular beds, Circ. Res., 19: 394.PubMedCrossRefGoogle Scholar
  15. Freis, E.D., Heath, W.C., Luchsinger, P.C. and Snell, R.E., 1967, Changes in the carotid pulse which occur with age and hypertension, Am. Heart J., 71: 757.CrossRefGoogle Scholar
  16. Gentile, B.J., Gross, D.R., Chuong, C.J.C. and Hwang, N.H.C., 1988, Segmental volume distensibility of the canine thoracic aorta, in vivo, Cardiovasc. Res., 22: 385.PubMedCrossRefGoogle Scholar
  17. Gozna, E.R., Marble, A.E., Shaw, A. and Holland, J.G., 1974, Age-related changes in the mechanics of the aorta and pulmonary artery of man, J. Appl. Physiol., 36: 407.PubMedGoogle Scholar
  18. Gray, R.J., Handler, F.P., Blanche, J.O., Zuckner, J. and Blumenthal, H.T., 1953, Aging process of aorta and pulmonary artery in negro and white races, Arch. Pathol., 56: 238.Google Scholar
  19. Guard, H.R. and Bhende, J.M., 1953, Changes due to aging in the abdominal aorta, Ind. J. Med. Res., 41: 267.Google Scholar
  20. Hallock, P., 1934, Arterial elasticity in man in relation to age as evaluated by the pulse wave velocity method, Arch. Intern. Med., 54: 770.CrossRefGoogle Scholar
  21. Hallock, P. and Benson, I.C., 1937, Studies on the elastic properties of human isolated aorta, J. Clin. Invest., 16: 595.PubMedCrossRefGoogle Scholar
  22. Harkness, M.L.R., Harkness, R.D. and McDonald, D.A., 1957, The collagen and elastin of the arterial wall in the dog, Proc. Roy. Soc. Biol., 146: 541.PubMedCrossRefGoogle Scholar
  23. Hass, G.M., 1942, Elastic tissue, H. A study of the elasticity and tensile strength of elastic tissue isolated from the human aorta. Arch. Pathol., 34: 971.Google Scholar
  24. Landowne, M., 1958, The relation between intra-arterial pressure and impact pulse wavevelocity with regard to age and arteriosclerosis, J. Gerontol., 13: 153.PubMedCrossRefGoogle Scholar
  25. Langewouters, G.J., 1982, “Visco-elasticity of the human aorta in vitro in relation toGoogle Scholar
  26. pressure and age,“ Ph.D. Thesis, Vrije Universiteit, Amsterdam, the Netherlands.Google Scholar
  27. Latham, R.D., 1988, Pulse propagation in the systemic arterial tree, in: “Vascular Dynamics”, N. Westerhof and D. R. Gross, eds., Plenum Press, New York, N. Y.Google Scholar
  28. Leoroyd, B. and Taylor, M.G., 1966, Alterations with age in the viscoelastic properties of human arterial walls, Circ. Res., 18: 278.CrossRefGoogle Scholar
  29. Milch, R.A., 1965, Matrix properties of the aging arterial wall, Mono. Surg. Sci., 2:261. Mirsky, I. and Janz, R.F., 1976, The effect of age on wall stiffness and human thoracic aorta: A large deformation “anisotropic” analysis, J. Theor. Biol., 59: 467.Google Scholar
  30. Moritz, A.R. and Oldt, M.R., 1937, Arteriolar sclerosis in hypertension and nonhypertensives, Am. J. Pathol., 13: 679.PubMedGoogle Scholar
  31. Mozersky, D.J., Sumner, D.S., Hokanson, D.E. and Strandness, D.E., 1973, Transcutaneous measurement of arterial wall properties as a potential method of estimating age, J. Am. Geriatr. Soc., 21: 18.PubMedGoogle Scholar
  32. Murgo, J.P., Westerhof, N., Giolma, J.P. and Altobelli, S.A., 1980, Aortic input impedance in normal man: relationship to pressure wave slope, Circulation, 62: 105.PubMedCrossRefGoogle Scholar
  33. Murgo, J.P., Westerhof, N., Giolma, J.P. and Altobelli, S.A., 1981(a), Manipulation of ascending aortic pressure and flow reflections with the Valsalva maneuver: relationship to input impedance, Circulation, 63: 122.Google Scholar
  34. Murgo, J.P., Westerhof, N., Giolma, I.P. and Altobelli, S.A., 1981(b), Effects of exercise on aortic input impedance and pressure wave forms in normal humans, Circ. Res., 48: 334.Google Scholar
  35. Myers, V.C. and Lang, W.W., 1946, Some chemical changes in the human thoracic aorta accompanying the aging process, J. Gerontol., 1: 441.PubMedCrossRefGoogle Scholar
  36. Nakashima, T. and Tanikawa, J., 1971, A study of human aortic distensibility with relation to atherosclerosis and aging, Angiology, 22: 477.PubMedCrossRefGoogle Scholar
  37. Newman, D.L. and Lallemand, R.c., 1978, The effect of age on the distensibility of the abdominal aorta of man, Surg. Gyn. Obst., 147: 211.PubMedGoogle Scholar
  38. Nichols, W.W. and McDonald, D.A., 1972, Wave velocity in the proximal aorta, Med. Biol. Eng. Comp., 10: 327.CrossRefGoogle Scholar
  39. Nichols, W.W., O’Rourke, M.F., Avolio, A.P., Yaginuma, T., Murgo, J.P., Pepine, C.J. and Conti, C.R., 1985, Effects of age on ventricular-vascular coupling, Am. J. Cardiol., 55: 1179.PubMedCrossRefGoogle Scholar
  40. Nichols, W.W., O’Rourke, M.f., Avolio, A.P., Yaginuma, T., Murgo, J.P., Pepine, C.J. and Conti, C.R., 1987, Age-related changes in left ventricular/arterial coupling, in: “Ventricular/Vascular Coupling,” F.C.P. Yin, ed., Springer-Verlag, New York.Google Scholar
  41. Nielson, B.L., Nielsen, J.S. and Fabricius, J., 1968, Pulse wave velocity in the human aorta, J. Am. Geriatr. Soc., 16: 647.Google Scholar
  42. O’Rourke, M.F., Avolio, A.P. and Nichols, W.W., 1987, Left ventricular-systemic arterial coupling in humans and strategies to improve coupling in disease states, in: “Ventricular/Vascular Coupling,” F.C.P. Yin, ed., Springer-Verlag, New York.Google Scholar
  43. O’Rourke, M.F., Blazek, J.V., Morreels, C.L. and Kronetz, L.T., 1968, Pressure wave transmission along the human aorta: changes with age and in arterial degenerative disease, Circ. Res., 23: 567.PubMedCrossRefGoogle Scholar
  44. O’Rourke, M.F. and Taylor, M.G., 1966, Vascular impedance of the femoral bed, Circ. Res., 18: 126.CrossRefGoogle Scholar
  45. Pagani, M., Baig, H., Sherman, A., Manders, W.T., Quinn, P., Patrick, T., Franklin, D. and Vatner, S.F., 1978, Measurement of multiple simulatneous small dimensions and study of arterial pressure-dimension relations in conscious animals, Am. J. Physiol., 235: H610.PubMedGoogle Scholar
  46. Patel, D.J., Coleman, B.R., Tearney, R.J., Cothran, L.N., and Curry, C.L., 1988, Peripheral vascular compliance, in: “Vascular Dynamics”, N. Westerhof and D. R. Gross, eds., Plenum Press, New York, N.Y.Google Scholar
  47. Patel, D.J. Mallos, A.J. and Fry, D.L., 1961, Aortic mechanics in the living dog. J. Appl. Physiol., 16: 293.Google Scholar
  48. Patel, D.J. and Fry, D.L., 1964, In situ pressure-radius-length measurements in ascending aorta of anesthetized dogs, J. Appl. Physiol., 19: 413.Google Scholar
  49. Patel, D.J. and Vaishnav, R.N., 1977, Mechanical properties of arteries, in: “Cardiovascular flow dynamics and measurements,” N.H.C. Hwang and N.R. Norman, eds., University Park Press, Baltimore.Google Scholar
  50. Puls, R.J. and Heizer, R.W., 1967, Pulse wave changing with aging, J. Am. Geriatr. Soc., 15: 153.PubMedGoogle Scholar
  51. Richter, H.A. and Mittermayer, C.H., 1984, Volume elasticity, modulus of elasticity and compliance of normal and arteriosclerotic human aorta, Biorheology, 21: 723.PubMedGoogle Scholar
  52. Roach, M.R. and Burton, A.C., 1959, The effect of age on the elasticity of human iliac arteries, Can. J. Biochem. Physiol., 37: 557.PubMedCrossRefGoogle Scholar
  53. Roy, C.S., 1880, The elastic properties of the arterial wall, J. Physiol. (Lond.), 3:125. Schimmler, W. 1966, Correlation between the pulse wave velocity in the aortic iliac vessel and age, sex and blood pressure, Angiology, 17: 314.Google Scholar
  54. Simonson, E. and Nakagawa, K., 1960, Effect of age on pulse wave velocity and aortic ejection time in healthy men and in men with coronary artery disease, Circulation, 22: 126.PubMedCrossRefGoogle Scholar
  55. Stehbens, W.E., 1979, “Hemodynamics and the Blood Vessel Wall,” Thomas, Springfield, IL.Google Scholar
  56. Suga, H., Goto, Y., Nozawa, T., Yasumura, Y., Futaki, S. and Tanaka, N., 1987, Force-time integral decreases with ejection despite constant oxygen consumption and pressure-volume area in dog left ventricle, Circ. Res., 60: 797.PubMedCrossRefGoogle Scholar
  57. Suga, H. and Sagawa, K., 1974, Instantaneous pressure-volume relationship and their ratio in the excised, supported canine left ventricle, Circ. Res., 35: 117.PubMedCrossRefGoogle Scholar
  58. Toorop, P.G., Westerhof, N. and Elzinga, G., 1987, Beat-to-beat estimation of peripheral resistance and arterial compliance during pressure transients, Am. J. Physiol., 252(21):HI275.Google Scholar
  59. van den Horn, G.J., Westerhof, N. and Elizinga, G., 1985, Optimal power generation by the left ventricle, Circ. Res., 56: 252.PubMedCrossRefGoogle Scholar
  60. Yin, F.C.P., 1987, Aging and Vascular impedance, in: “Ventricular/Vascular Coupling,” F.C.P. Yin, ed., Springer-Verlag, New York.CrossRefGoogle Scholar
  61. Yin, F.C.P., Spurgeon, H.A. and Kallman, C.H., 1983, Age-associated alterations in viscoelastic properties of canine aortic strips, Circ. Res., 53: 464.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • David R. Gross
    • 1
  1. 1.Physiology and Applied Physics Laboratory Department Veterinary Physiology and Pharmacology College of Veterinary MedicineTexas A&M UniversityCollege StationUSA

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