Vascular Graft Materials and Their Structure
It is well-known that thromboresistance, compliant properties and good healing are 3 major requisites for vascular grafts. These are closely interrelated and correlated with both the bio-chemical properties and the details of structure, such as porosity, of vascular graft materials. In this study a hydrogel (HM) which ionically combines heparin and a hydrogel (H-PEO) with long polyethylene oxide (PEO) chains have been developed as thromboresistant materials. The effects of the heparin release profile and of the chain length of PEO on the thromboresistance were studied in both the HM and the H-PEO. A thromboresistant material for vascular grafts, a hydrogel (HMN) with PEO chains which releases heparin has been developed. A new vascular graft has also been developed using ultra fine polyester fibers. The effects of fineness of vascular graft fiber on mechanical properties and the healing process were investigated.
KeywordsThrombus Formation Vascular Graft Fibrin Deposition Polyester Fiber Polyethylene Oxide
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- Okamoto, M., 1981, Ultra-fine fiber and its application, preprints, Japan-China Bilateral Symposium on Polymer Science and Technology, 256, Tokyo, October.Google Scholar
- Noishiki, Y., Watanabe, K., Okamoto, M., Kikuchi, Y., and Mori, Y., 1986, Evaluation of a new vascular graft prosthesis fabricated from ultrafine polyester fiber, Trans. Am. Soc. Artif. Intern. Organs, 32: 309.Google Scholar
- Mori, Y., Nagaoka, S., Masubuchi, Y., Itoga, M., Tanzawa, H., Kikuchi, T., Yamada, Y., Yonaha, T., Watanabe, H., and Idezuki, Y., 1978, The effect of released heparin from the heparinized hydrophilic polymer (H-RSD) on the process of the thrombus formation, Trans. Am. Soc. Artif. Intern. Organs, 24: 736.PubMedGoogle Scholar
- Idezuki, Y., Watanabe, H., Hagiwara, M., Kanasugi, K., Mori, Y., Nagaoka, S., Hagio, H., Yamamoto, K., and Tanzawa, H., 1978, Mechanism of antithrombogenicity of a new heparinized hydrophilic polymer: Chronic in vivo studies and clinical application, Trans. Am. Soc. Artif. Intern. Organs, 21: 436.Google Scholar
- Wesolowski, S.A., 1962, “Evaluation of Tissue and Prosthetic Vascular Grafts,” Charles C. Thomas, Springfield.Google Scholar
- Noishiki, Y., Miyata, T., and Kodaira, K., 1986, Development of a small caliber vascular graft by a new crosslinking method incorporating slow heparin release collagen and natural tissue compliance, Trans. Am. Soc. Artif. Intern. Organs, 32: 114.Google Scholar