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Vascular Graft Materials and Their Structure

  • Yuichi Mori
Part of the NATO ASI Series book series (volume 166)

Abstract

It is well-known that thromboresistance, compliant properties and good healing are 3 major requisites for vascular grafts. These are closely interrelated and correlated with both the bio-chemical properties and the details of structure, such as porosity, of vascular graft materials. In this study a hydrogel (HM) which ionically combines heparin and a hydrogel (H-PEO) with long polyethylene oxide (PEO) chains have been developed as thromboresistant materials. The effects of the heparin release profile and of the chain length of PEO on the thromboresistance were studied in both the HM and the H-PEO. A thromboresistant material for vascular grafts, a hydrogel (HMN) with PEO chains which releases heparin has been developed. A new vascular graft has also been developed using ultra fine polyester fibers. The effects of fineness of vascular graft fiber on mechanical properties and the healing process were investigated.

Keywords

Thrombus Formation Vascular Graft Fibrin Deposition Polyester Fiber Polyethylene Oxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Yuichi Mori
    • 1
  1. 1.Membrane & Biosystems Department Japan Research CenterW.R. GRACE & Co.Japan

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