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Vascular Tissue Response to Experimentally Altered Local Blood Flow Conditions

  • B. Lowell Langille
  • Avrum I. Gotlieb
  • Don W. Kim
Part of the NATO ASI Series book series (volume 166)

Abstract

Local factors related to shear stress may influence atherogenesis through several mechanisms. It is probably for this reason that lesion development does not show a consistent relation to shear stress when different experimental models are compared. Thus, there is currently emphasis on the correlation that has been observed between low shear and lesion formation in several experimental models, for example, the human carotid bifurcation studied by Ku and co-workers (1985).As these investigators point out, however, it is often difficult to divorce low shears from shears that fluctuate rapidly in magnitude and especially in direction. Furthermore, atherosclerosis occurs in high shear regions in some models, although it now appears that this is not commonplace and tends to be species specific. Indeed, frequent sparing of high shear regions has raised speculations of adaptive responses to shear. Finally, it frequently appears that reproducible lesions may be distributed at sites not well correlated with shear stress. Thus, the distribution of lesions within the aorta of animals or humans is not readily related to available maps of aortic shear in mammals.

Keywords

Shear Stress Aortic Coarctation Secondary Vortex Carotid Artery Occlusion Endothelial Cell Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Avolio, A.P., O’Rourke, M.F., Mang, K., Boson, P.T., and Gow, B.S., 1976, Comparative study of pulsatile arterial hemodynamics in rabbits and guinea pigs, Am. J. Physiol., 230: 868.PubMedGoogle Scholar
  2. Barak, L.S., Yocum, R.R., Nothnagel, E.A., and Webb, W.W., 1980, Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-z-oxa-1, 3-diazolephallicidin, Proc. Natl. Acad. Sci. USA, 77: 980.PubMedCrossRefGoogle Scholar
  3. Borgdorff, P., and van den Horn, G.J., 1980, The effect of common carotid arteryGoogle Scholar
  4. occlusion on blood pressure in the barodenervated cat, Pfluegers Arch.,386:193. Gjedde, S.B., and Gjedde, A., 1980, Organ blood flow rates and cardiac output of the BALB-C mouse, Comp. Biochem. Physiol.,67A:671.Google Scholar
  5. Glagov, S., Weisenberg, E., Zarins, C.K., Stankunavicuis, R., and Kolettes, G.J., 1987, Compensatory enlargement of human atherosclerotic coronary arteries, New Engl. J. Med., 316: 1371.PubMedCrossRefGoogle Scholar
  6. Guyton, J.R., and Hartley, C.J., 1985, Flow restriction of one carotid artery in juvenile rats inhibits growth of arterial diameter, Am. J. Physiol., 248: H540.PubMedGoogle Scholar
  7. Hansonn, G.K., and Schwartz, S.M., 1983, Evidence for cell death in the vascular endothelium in vivo and in vitro, Am. J. Pathol., 112: 278.Google Scholar
  8. Karino, T., and Goldsmith, H.L., 1979, Adhesion of human platelets to collagen on the walls distal to a tubular expansion, Microvas. Res., 17: 238.CrossRefGoogle Scholar
  9. Kisouzi, S.N., 1980, Simultaneous measurements of cardiac output and of hepatic and portal blood flows in conscious sheep, Irish J. Med., 149: 44.Google Scholar
  10. Ku, D.N., Giddens, D.P., Zarins, C.K., and Glagov, S., 1985, Pulsatile flow and atherosclerosis in the human carotid bifurcation: positive correlation between plaque location and low oscillating shear stress, Arteriosclerosis, 5: 293.PubMedCrossRefGoogle Scholar
  11. Langille, B.L., and O’Donnell, F., 1986, Reductions in arterial diameter produced by chronic decrease in blood flow are endothelium-dependent, Science, 231: 405.PubMedCrossRefGoogle Scholar
  12. Langille, B.L., Reidy, M.A., and Kline, R.L., 1986, Injury and repair of endothelium at sites of flow disturbances near abdominal aortic coarctations in rabbits, Arteriosclerosis, 6: 146.PubMedCrossRefGoogle Scholar
  13. Macagno, E.O., and Hung, T.-K., 1967, Computational and experimental study of a captive annular eddy, J. Fluid Mech., 28: 43.CrossRefGoogle Scholar
  14. Reidy, M.A., and Schwartz, S.M., 1981, Endothelial regeneration. III. Time course of intimal changes after smell defined injury to rat aortic endothelium, Lab. Invest., 44: 301.PubMedGoogle Scholar
  15. Trippodo, N.C., Walsh, G.M., Ferrone, R.A., and Dugan, R.C., 1979, Fluid partition and cardiac output in volume depleted Goldblatt hypertensive rats, Am. J. Physiol., 237: H18.PubMedGoogle Scholar
  16. Verteeg, P.G.A., Sampurno, S.B., Sipkema, P., and Elzinga, G., 1981, Control of cardiac output in exercising dogs using different types of workload, Cardiovasc. Res., 15: 151.CrossRefGoogle Scholar
  17. Wolinsky, H., and Glagov, S., 1969, Comparison of abdominal and thoracic aortic medial structure in mammals, Circ. Res., 25: 667.CrossRefGoogle Scholar
  18. Wong, M.K.K., and Gotlieb, A.I., 1986, Endothelial cell monolayer integrity. I. Characterization of dense peripheral band of microfilaments, Arteriosclerosis, 6: 212.PubMedCrossRefGoogle Scholar
  19. Wysolemerski, R., and Langunoff, D., 1985, The effect of etchlorvynol on cultured endothelial cells, Am. J. Pathol., 119: 505.Google Scholar
  20. Yamaguchi, T., and Hanai, S., 1988, To what extent does a minimal atherosclerotic plaque alter the arterial wallshear stress distribution? A model study by an electrochemical method, Biorheology, 25: 31.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • B. Lowell Langille
    • 1
  • Avrum I. Gotlieb
    • 1
  • Don W. Kim
    • 1
  1. 1.Vascular Research Laboratory Max Bell Research CentreToronto HospitalTorontoCanada

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