Shear Stress in Atherogenesis

  • Morton H. Friedman
Part of the NATO ASI Series book series (volume 166)


In this paper, the nature of the shear environment in the large vessels, and the arguments that support a role for shear stress in atherogenesis, are discussed. The work that needs to be done to develop these arguments more rigorously and from a mechanistic point of view is summarized briefly.


Shear Rate Wall Shear Stress Laser Doppler Anemometry Intimal Thickness Aortic Bifurcation 
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  1. Davies, P.F., Truskey, G.A., Warren, H.B., O’Connor, S.E. and Eisenhaure, B.H., 1985, Metabolic cooperation between vascular endothelial cells and smooth muscle cells in coculture, J. Cell Biol., 101: 871.PubMedCrossRefGoogle Scholar
  2. Deters, O.J., Bargeron, C.B., Mark, F.F. and Friedman, M.H., 1987, Variability of wall shear and geometry at the human aortic bifurcation, in: “1987 Biomechanics Symposium”, D.L. Butler, and P.A. Torzilli, eds. Amer. Soc. Mech. Engrs., New York, 45–48.Google Scholar
  3. Friedman, M.H., 1987, The relationship between intimai thickening and the hemodynamic environment of the arterial wall, Proc. Int’l Symp. on the Role of Blood Flow in Atherogenesis, Osaka, I21.Google Scholar
  4. Friedman, M.H., Bargeron, C.B., Deters, O.J., Hutchins, G.M. and Mark, F.F., 1987, Correlation between wall shear and intimai thickness at a coronary artery branch, Atherosclerosis, 68: 27.PubMedCrossRefGoogle Scholar
  5. Friedman, M.H. and Deters, O.J., 1987, Correlation among shear rate measures in vascular flows, J. Biomech. Eng., 109: 25.PubMedCrossRefGoogle Scholar
  6. Friedman, M.H., Deters, O.J., Bargeron, C.B., Hutchins, G.M., and Mark, F.F., 1986, Shear-dependent thickening of the human arterial intima, Atherosclerosis, 60: 161PubMedCrossRefGoogle Scholar
  7. Friedman, M.H., Hutchins, G.M., Bargeron, C.B., Deters, O.J., and Mark, F.F., 1981, Correlation of human arterial morphology with hemodynamic measurements in arterial casts, J. Biomech. Eng., 103: 204.PubMedCrossRefGoogle Scholar
  8. Kamiya, A., Bukhari, R. and Togawa, T., 1984, Adaptive regulation of wall shear stress optimizing vascular tree function, Bull. Math. Biol., 46: 127.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Morton H. Friedman
    • 1
  1. 1.The Ohio State UniversityColumbusUSA

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