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Endothelium in Hemostasis and Thrombosis

  • Philip G. de Groot
  • Hetty C. de Boer
  • Pim N. M. Tijburg
  • Jaap Jan Zwaginga
Part of the NATO ASI Series book series (volume 166)

Abstract

In the normal vasculature, blood platelets circulate freely through the vessels and no fibrin is formed. The capacity of the endothelium, which forms the inner lining of the blood vessel wall, to inhibit the activation of the coagulation cascade and to prevent platelet adhesion has been called “non-thrombogenicity”. The endothelium consists of a monolayer of cells, which have, under normal conditions, two different sites. The apical site faces the blood stream and is non-thrombogenic. On the basal site the cells synthesize an extracellular matrix, the subendothelium, which has thrombogenic properties. After contraction or desquamation of endothelial cells platelets rapidly adhere to the exposed subendothelium.

Keywords

Endothelial Cell Shear Rate Tissue Factor Platelet Adhesion Fluid Shear Stress 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Philip G. de Groot
    • 1
  • Hetty C. de Boer
    • 1
  • Pim N. M. Tijburg
    • 1
  • Jaap Jan Zwaginga
    • 1
  1. 1.Department of HaematologyUniversity Hospital UtrechtUtrechtThe Netherlands

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