Neuropathology of the Werner Syndrome

  • S. M. Sumi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 190)


In his original report, Werner (1) described four siblings who had in common shortness of stature, senile appearance, early graying of the hair and appearance of cataracts, skin changes and early cessation of menstruation. Subsequent authors added premature balding, tendency to diabetes mellitus and calcification of blood vessels to this picture. Although patients with this syndrome appear to exhibit premature aging, evidence for this is difficult to document (2), and this is particularly true with regard to the central nervous system.


Senile Plaque Premature Aging Werner Syndrome Neurofibrillary Degeneration Lipofuscin Granule 


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • S. M. Sumi
    • 1
  1. 1.University of WashingtonDepartment of PathologySeattleUSA

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