Pathology of the Werner Syndrome

  • Toshiharu Ishii
  • Yasuhiro Hosoda
  • Yoshiro Hamada
  • Sadaaki Nakagawa
  • Goro Asano
  • Yoshimune Horibe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 190)


Anatomic-pathological observation remains one of the fundamental approaches to the understanding of multiple system disease of unknown etiology. In this paper, we review the results of such anatomic investigations of necropsies of subjects with the Werner syndrome, including five cases (all Japanese subjects) that we have personally autopsied, one of which (Case 5) has not been previously reported.


Follicular Adenoma Vertebral Bone Werner Syndrome Japanese Case Sympathetic Ophthalmia 
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  1. Asano, G., Aihara, K., Ito, T. and Yamate, N., 1970, An autopsy case of Werner’s syndrome, Nippon Ika Daig. Z., 37: 162.Google Scholar
  2. Boyd, M.W.J. and Grant, A.P., 1950, Werner’s syndrome (progeria of the adult): Further pathological and biochemical observation, Brit. Med. J., 2: 920.CrossRefGoogle Scholar
  3. Dawber, T, 1980, The Framingham Study, Harvard University Press, Boston.Google Scholar
  4. Dudl, R.J. and Ensinck, J.W., 1977, Insulin and glucagon relationships during aging in man, Metabolism, 26: 33.PubMedCrossRefGoogle Scholar
  5. Goto, M., Horiuchi, Y., Okumura, K. and Tada, T., 1979, Immunological abnormalities of aging. An analysis of T lymphocyte subpopulation of Werner’s syndrome, J. Clin. Invest., 64: 695.PubMedCrossRefGoogle Scholar
  6. Goto, M., Horiuchi, Y., Tanimoto, K., Ishii, T. and Nakashima, H., 1978, Werner’s syndrome: Analysis of 15 cases with a review of the Japanese literature, J. Am. Geriatrics Soc., 26: 341.Google Scholar
  7. Hamada, Y., 1966, Werner’s syndrome: Report of a case with portmortem findings. Dermatologica et Urologica (Tokyo) 20: 1321.Google Scholar
  8. Ishii, T. and Hosoda, Y., 1975, Werner’s syndrome: Autopsy report of one case, with a review of pathologic findings reported in the literature, J. Am. Geriatrics Soc., 23: 145.Google Scholar
  9. Ishii, T., Hosoda, Y., Ikegami, N. and Shimada, H., 1984, Senile amyloid deposition, J. Path. 139: 1.Google Scholar
  10. Ishii, T., Maeda, K., Nakamura, K. and Hosoda, Y., 1979, Cancer in the aged: An autopsy study of 940 cancer patients, J. Am. Geriatrics Soc., 27: 307.Google Scholar
  11. Ishii, T. and Sternby, N.H., 1978a, Pathology of centenarians. I. The cardiovascular system and the lungs, J. Am. Geriatrics Soc., 26: 108.Google Scholar
  12. Ishii, T. and Sternby, N.H., 1978b, Pathology of centenarians. II. Urogenital and digestive systems, J. Am. Geriatrics Soc., 26: 391.Google Scholar
  13. Ishii, T. and Sternby, N.H., 1978c, Pathology of centenarians. III. Osseous system, malignant lesions and causes of death, J. Am. Geriatrics Soc., 26: 529.Google Scholar
  14. Jacobson, H.G., Rifkin, H. and Zucker-Franklin, D., 1960, Werner’s syndrome. A clinicoroentgen entity, Radiology. 74: 373.PubMedGoogle Scholar
  15. Kizukuri, T., Katoh, M., Uesugi, T. and Jimbow, K., 1980, Werner’s syndrome with malignant melanoma, Nippon Hifuka Gakkai Zasshi, 90: 677.PubMedGoogle Scholar
  16. Laugier, P., Ellena, V., Risold, J.C., Bulte, C., Oppermann, A. and Pageaut, G., 1967, Syndrome de Werner: Constatations necropsiques, Bull. Soc. Franc. Derm. Syph., 74: 38.PubMedGoogle Scholar
  17. Nakagawa, S., Shinohara, K., Kojima, H., Ishikawa, F. and Murakami, T., 1974, An autopsy case of Werner’s syndrome associated with leiomyosarcoma, Jap. J. Clin. Med., 32: 859.Google Scholar
  18. Oppenheimer, B.S. and Kugel, V.H., 1941, Werner’s syndrome: Report of first necropsy and of findings in new cases, J. Am. Med. Sci.,, 202: 629.CrossRefGoogle Scholar
  19. Pavlik, F. and Korp, W., 1971, Werner-syndrom, Wien Med. Wschr., 121:87.Google Scholar
  20. Perloff, J.K. and Phelps, E.T., 1958, A review of Werner’s syndrome with a report of the second autopsied case, Ann. Intern. Med., 48: 1205.PubMedGoogle Scholar
  21. Resch, J.A., Okabe, N., Loewenson, R.B., Kimoto, K., Katsuki, S. and Baker, A.B., 1969, Pattern of vessel involvement in cerebral atherosclerosis, J. Atheroscl. Res., 9: 239.CrossRefGoogle Scholar
  22. Rogers, A.S., 1958, Werner’s syndrome, J. Florida Med. Assn., 46: 436.Google Scholar
  23. Schott, J. and Dann, S., 1949, Werner’s syndrome: A report of 2 cases, New Engl. J. Med., 240: 641.Google Scholar
  24. Tajima, T., Iijima, K. and Watanabe, T., 1978, Collagen synthesis of cultured fibroblast from Werner’s syndrome of premature aging, Experientia, 34: 1459.PubMedCrossRefGoogle Scholar
  25. Tokunaga, M., Futami, T. and Wakamatsu, E., 1975, Werner’s syndrome as ‘hyaluronuria,’ Clin. Chim. Acta, 62: 89.PubMedCrossRefGoogle Scholar
  26. Tokunaga, M., Mori, S., Sato, K., Nakamura, K. and Wakamatsu, E., 1976, Postmortem study of a case of Werner’s syndrome, J. Am.. Geriatrics Soc., 24: 407.Google Scholar
  27. Valero, A. and Gellei, B., 1960, Retinitis pigmentosa, hypertension and uremia in Werner’s syndrome, Brit. Med. J., 2: 351.PubMedCrossRefGoogle Scholar
  28. Zucker-Franklin, D., Rifkin, H. and Jacobson, H.G., 1968, Werner’s Syndrome: An analysis of ten cases, Geriatrics, 23: 123.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Toshiharu Ishii
    • 1
  • Yasuhiro Hosoda
    • 1
  • Yoshiro Hamada
    • 2
  • Sadaaki Nakagawa
    • 3
  • Goro Asano
    • 4
  • Yoshimune Horibe
    • 5
  1. 1.Departments of PathologyUniversity School of MedicineShinjukuku, Tokyo 160Japan
  2. 2.DermatologyNumazu Municipal HospitalShinjukuku, Tokyo 160Japan
  3. 3.Departments of PathologyKawasaki Medical SchoolShinjukuku, Tokyo 160Japan
  4. 4.Departments of PathologyNippon Medical SchoolShinjukuku, Tokyo 160Japan
  5. 5.Departments of Pathologyand Nagoya Fujita Gakuen Medical SchoolShinjukuku, Tokyo 160Japan

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