Werner Syndrome: A Review of Recent Research with an Analysis of Connective Tissue Metabolism, Growth Control of Cultured Cells, and Chromosomal Aberrations

  • Darrell Salk
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 190)


Werner syndrome is a rare, autosomal recessive condition with multiple progeroid features, but it is a phenocopy of aging rather than accelerated or premature senescence. Somatic chromosome aberrations occur in multiple tissues in vivo and in vitro and there is an increased incidence of neoplasia. Thus, Werner syndrome can be classified in the group of chromosome instability syndromes. Recent findings provide additional support for the concept that there is an aberration of connective tissue metabolism in Werner syndrome, but it is unclear whether this is a primary or secondary manifestation of the underlying genetic defect. Abnormal growth characteristics are observed in cultured skin fibroblast-like cells and this provides another avenue for current research. Identification of the basic genetic defect in Werner syndrome might clarify our understanding of the normal aging process in general, or might elucidate specific aspects such as the development of neoplasia, atherosclerosis, diabetes, or osteoporosis.


Hyaluronic Acid Fanconi Anemia Werner Syndrome Bloom Syndrome Autosomal Recessive Condition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Plenum Press, New York 1985

Authors and Affiliations

  • Darrell Salk
    • 1
  1. 1.Division of Genetic Pathology, SM-30University of WashingtonSeattleUSA

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