The Notion of Primordial Building Blocks in Construction of Genes and Transcriptional and Processing Errors Due to Random Occurrence of Oligonucleotide Signal Sequences

  • Susumu Ohno
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 190)


Contrary to the currently popular belief, genes (flanking and internal noncoding sequences included) that specify beta-sheet and alpha-helical proteins are not unique sequences, rather they are degenerate repeats of short primordial building block sequences that are 45 to 48 bases long in the case of genes belonging to the beta-2-microglobulin superfamily. Accordingly, a large number of base decamers, nonomers, octamers, heptamers and hexamers recur within every gene.


Human Class Balbiani Ring Domain Code Sequence Base Oligomer Degenerate Repeat 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Susumu Ohno
    • 1
  1. 1.City of Hope Research InstituteDuarteUSA

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