Acidic Glycosaminoglycans in Werner’s Syndrome: Studies on Levels in Tissue, Organ, Cell, and Fluid

  • Katsumi Muratal
  • Ryoichi Hiwatari
  • Toshiharu Matsumura
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 190)


The clinical manifestations of Werner’s syndrome resemble those of the normal aging process (Werner, 1904; Epstein et al., 1966; Murata and Nagashima, 1982). Scleroderma-like features and cataracts are the main symptoms of Werner’s syndrome in the original description (Werner, 1904). It is a genetic disorder disease affecting the mesodermal connective tissues of the whole body (Fleischmajer and Nedwich, 1973) of which acidic glycosaminoglycans (AGAG) are one component. Some of the degraded components of these AGAG are excreted in urine as catabolic products. In normal subjects, urinary AGAG comprise small amounts of chondroitin 4-sulfate (C-4S), chondroitin 6-sulfate (C-6S), and heparan sulfate (HS) and even smaller amounts of other chondroitin sulfate (CS) isomers (Varadi, 1967; Murata et al., 1971; Wessler, 1971; Taniguchi, 1972). Hyaluronic acid (HA) is absent or in trace amounts (Varadi et al., 1967).


Hyaluronic Acid Iliac Artery Heparan Sulfate Chondroitin Sulfate AGAG Content 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Katsumi Muratal
    • 1
  • Ryoichi Hiwatari
    • 2
  • Toshiharu Matsumura
    • 3
  1. 1.Department of Medicine and Physical Therapy Faculty of MedicineUniversity of TokyoBunkyo-ku, Tokyo 113Japan
  2. 2.The Third Department of MedicineKagoshima University School of MedicineKagoshimaJapan
  3. 3.Institute of Medical ScienceUniversity of TokyoJapan

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