Analysis of Cellular Senescence through Detection and Assessment of RNAs and Proteins Important to Gene Expression: Transfer RNAs and Autoimmune Antigens

  • Paul F. Agris
  • Andra Boak
  • Joseph W. Basler
  • Catherine Van Voorn
  • Christine Smith
  • Morris Reichlin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 190)


Gene expression is altered in Werner’s syndrome (Salk, 1982). Investigation of how, when, and where these alterations occur requires fundamental understanding of the regulation of genes in normal states--during development and aging--and in diseased organisms. Unfortunately, much of this information is lacking; therefore, only specific aspects of gene expression in Werner’s syndrome can be compared to the normal counterpart with any real understanding. However, newly designed tools in biochemistry and immunology have opened areas of investigation previously unaccessible.


High Performance Liquid Chromatography Cell Strain Cellular Senescence Population Doubling Hemagglutination Inhibition 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Paul F. Agris
    • 1
  • Andra Boak
    • 1
  • Joseph W. Basler
    • 1
  • Catherine Van Voorn
    • 1
  • Christine Smith
    • 1
  • Morris Reichlin
    • 2
  1. 1.Division of Biological Sciences and the Department of MedicineUniversity of MissouriColumbiaUSA
  2. 2.Oklahoma Medical Research FoundationOklahoma CityUSA

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