Cellular Mechanisms of Aging in the Werner Syndrome

  • Osamu Nikaido
  • Taka Nishida
  • Akihiro Shiga
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 190)


The Werner syndrome (WS) is a rare autosomal recessive disease with characteristic features of accelerated ageing such as gray hair, dwarfism, juvenile cataract1), urinary excretion of high levels of acidic glycosaminoglycans2) and a short life span. Many attempts to elucidate the relatively short life spans of patients with various progeroid syndromes by using cultured cells have been made in the past two decades3,4). Among them, the reduction in population doubling numbers (PDs) in cells derived from the patients with genetic disorders such as WS3) and Hutchinson-Gilford progeria4) gave us a clue to the finding of a causal relationship between the clinical symptoms and biological defects found in these cells.


Herpes Simplex Virus Ataxia Telangiectasia Ataxia Telangiectasia Werner Syndrome Label Intensity 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Osamu Nikaido
    • 1
  • Taka Nishida
    • 1
  • Akihiro Shiga
    • 2
  1. 1.Division of Radiation Biology Faculty of Pharmaceutical SciencesKanazawa UniversityKanazawa 920Japan
  2. 2.Department of Experimental RadiologyShiga University of Medical ScienceOhtsuJapan

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