Clinical and Metabolic Studies on Werner’s Syndrome: With Special Reference to Disorders of Lipid and Liver Function

  • Katsumi Murata
  • Hiroaki Nakashima
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 190)


Werner’s syndrome was first described by Werner (1904) as a mesodermal disorder clinically characterized by multifarious facets of premature senility. Numerous papers on Werner’s syndrome have since been written (Oppenheimer and Kugel 1934; Thannhauser 1945; Irwin and Ward 1953; Epstein et al., 1966). However, reports of a disorder of lipid metabolism and liver dysfunction were limited (Zucker-Franklin et al., 1968). The occurrence of Werner’s syndrome is relatively higher in Japan (Murata and Nakashima, 1982). To date, numerous clinical reports on this syndrome are to be found in the literature, but some of them are either incomplete or occasionally overlap. Only by cautious selection from among the publications in the medical literature, excluding incorrect cases, is it possible to reveal the clear-cut clinical features of this syndrome.


Hyaluronic Acid Achilles Tendon Werner Syndrome Nonesterified Fatty Acid Bilateral Cataract 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Katsumi Murata
    • 1
    • 2
  • Hiroaki Nakashima
    • 1
    • 2
  1. 1.Department of Medicine and Physical TherapyUniversity of Tokyo School of MedicineTokyoJapan
  2. 2.Third Department of MedicineKagoshima University School of MedicineKagoshimaJapan

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