Immunological Aspects of Werner’s Syndrome: An Analysis of 17 Patients

  • Makoto Goto
  • Kiyoaki Tanimoto
  • Terumasa Miyamoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 190)


The Werner syndrome, a caricature of aging, is characterized by a variety of clinical manifestations associated with natural aging. In brief, the Werner syndrome is a rare genetically determined disease inherited as an autosomal recessive trait. Patients manifest failure of the adolescent growth spurt, graying of hair in the teens, juvenile bilateral cataracts, mild diabetes mellitus, arteriosclerosis, and scleroderma-like skin changes. The average lifespan is 47 years (Goto et al., 1978, 1981). A high incidence of neoplasia of mesenchymal origin was also reported.


Systemic Lupus Erythematosus Peripheral Blood Lymphocyte Werner Syndrome Immunological Aspect Anticentromere Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Makoto Goto
    • 1
  • Kiyoaki Tanimoto
    • 1
  • Terumasa Miyamoto
    • 1
  1. 1.Department of Internal Medicine and Physical Therapy Faculty of MedicineUniversity of TokyoTokyoJapan

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