Clinical, Demographic, and Genetic Aspects of the Werner Syndrome in Japan

  • Makoto Goto
  • Fujio Takeuchi
  • Kiyoaki Tanimoto
  • Terumasa Miyamoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 190)


A total of 196 typical patients with the Werner syndrome, a caricature of aging, was studied to define the details of the clinical manifestations, demography and genetic aspects in Japan.

Most of the previously reported clinical characteristics and the autosomal recessive inheritance of this syndrome were confirmed, but no significant linkage was revealed between specific HLA type and the Werner syndrome. The frequency of the Werner syndrome in Japan was estimated using two methods which indicated approximately 300 cases among 100 million people.


Basal Metabolic Rate Genetic Aspect Consanguineous Marriage Werner Syndrome Progressive Systemic Sclerosis 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Makoto Goto
    • 1
  • Fujio Takeuchi
    • 1
  • Kiyoaki Tanimoto
    • 1
  • Terumasa Miyamoto
    • 1
  1. 1.Department of Internal Medicine and Physical Therapy Faculty of MedicineUniversity of TokyoBunkyo-ku, Tokyo 113Japan

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