Clinical, Demographic, and Genetic Aspects of the Werner Syndrome in Japan
A total of 196 typical patients with the Werner syndrome, a caricature of aging, was studied to define the details of the clinical manifestations, demography and genetic aspects in Japan.
Most of the previously reported clinical characteristics and the autosomal recessive inheritance of this syndrome were confirmed, but no significant linkage was revealed between specific HLA type and the Werner syndrome. The frequency of the Werner syndrome in Japan was estimated using two methods which indicated approximately 300 cases among 100 million people.
KeywordsBasal Metabolic Rate Genetic Aspect Consanguineous Marriage Werner Syndrome Progressive Systemic Sclerosis
Unable to display preview. Download preview PDF.
- Dahlberg, G., 1950, Methods for population genetics, Am. J. Biol. 25: 90–104.Google Scholar
- Epstein, C.J., Martin, G.M., Schultz, A.L., Motulsky, A.G., 1966, Werner’s syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process, Medicine, 45: 177–221.Google Scholar
- Goto, M., Urata, K., 1978, Urinary excretion of macromolecular acidic glycosaminoglycans in Werner’s syndrome, Clin. Chim. Acta, 85: 101–106.Google Scholar
- Goto, M., Horiuchi, Y., Tanimoto, K., Ishii, T., Nakashima, H., 1978, Werner’s syndrome: Analysis of 15 cases with a review of the Japanese literature, J. Am. Geriatr. Soc., 26: 341347.Google Scholar
- Goto, M., Tanimoto, K., Horiuchi, Y., Sasazuki, 1981, Family analysis of Werner’s syndrome: A survey of 42 Japanese families with a review of the literature, Clin. Genet. 19: 815.Google Scholar
- Ishida, R., 1917, A case of cataract in combination with scleroderma, Jap. J. Opthalmol., 21: 1025–1029.Google Scholar
- Martin, G.M., Sprague, C.A., Epstein, C.J., 1970, Replicative lifespan of cultivated human cells: Effects of donor’s age, tissue and genotype, Lab. Invest., 23: 86–91.Google Scholar
- Morton, N.E., 1959, Genetic tests under incomplete ascertainment, Am. J. Hum. Genet., 11: 1–16.Google Scholar
- Oppenheimer, B.S., Kugel, V.H., 1941, Werner’s syndrome: Report of the first necropsy and of findings in a new case, Am. J. Med. Soc., 202: 629–642.Google Scholar
- Salk, D., 1982, Werner’s syndrome: A review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations, Hum. Genet., 62: 1–15.Google Scholar
- Thannhauser, S.J., 1945, Werner’s syndrome (progeria of the adult) and Rothmund’s syndrome: Two types of closely related heredo-familial atrophic dermatosis with juvenileGoogle Scholar
- cataracts and endocrine features. A critical study with five new cases, Ann. Intern. Med., 23: 559–626.Google Scholar
- Tokunaga, M., Futami, T.; Wakamatsu, E., Endo, M., Yosizawa, Z, 1945, Werner’s syndrome as “hyaluronuria,” Clin. Chim. Acta., 62: 89–96.Google Scholar
- Werner, C.W.D., 1904, “Uber Katarakt in Verbingung mit Sklerodermie (doctoral dissertation, Kiel University ), Schmidt and Klauning, Kiel.Google Scholar
- Zucker-Franklin, D., Rifkin, H., Jacobson, H.G., 1968, Werner’s syndrome: An analysis of ten cases, Geriatrics, 23: 123–135.Google Scholar