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A Comparison of Adult and Childhood Progerias: Werner Syndrome and Hutchinson-Gilford Progeria Syndrome

  • W. Ted Brown
  • Fred J. Kieras
  • George E. HouckJr.
  • Regina Dutkowski
  • Edmund C. Jenkins
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 190)

Abstract

The Werner syndrome, also known as progeria of the adult, and the childhood Hutchinson-Gilford Progeria Syndrome (hereafter Progeria), both serve as genetic disease models of human aging (Brown, 1979). A comparison of their similarities and differences may be useful in order to gain insight into the nature of the genetic mutations underlying these conditions. Their modes of inheritance indicate the involvement of a single gene. This implies that some specific genes may lead to a phenotype of greatly accelerated senescence and that such genes may have direct effects on the rate of aging. Determining the basic mechanisms involved in producing their phenotypes may point the way to an understanding of important pathogenetic aspects underlying the aging process.

Keywords

Hyaluronic Acid Uronic Acid Werner Syndrome Sister Chromatid Exchange Frequency Crouzon Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • W. Ted Brown
    • 1
  • Fred J. Kieras
    • 1
  • George E. HouckJr.
    • 1
  • Regina Dutkowski
    • 1
  • Edmund C. Jenkins
    • 1
  1. 1.The New York State Institute for Basic Research in Developmental Disabilities, Staten IslandNew York and Cornell University Medical CollegeNew YorkUSA

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