Complex Dynamics in the Kidney Microcirculation

  • Donald J. Marsh
  • N.-H. Holstein-Rathlou
  • K.-P. Yip
  • Paul P. Leyssac
Part of the NATO ASI Series book series (NSSB, volume 270)


Maintaining the volume and composition of the body fluids within narrow bounds is one of the chief functions the kidneys perform. The successful achievement of this goal provides other tissues and organs the stable environment needed for their own particular functions. One of these other organs is the heart, whose action leads to perfusion with blood of organs like the kidney. The proper function of the kidneys depends on adequate blood perfusion, and the kidneys play an especially important role in blood pressure regulation by maintaining the volume of the extracellular fluid, and therefore of the blood. Normal blood volume is important for the heart to achieve stable blood pressure. The relationships between renal function and blood pressure regulation form an essential duality that is crucial to normal function, and that fails in a number of disease states. The interaction between kidney function and blood pressure regulation occurs at a number of points, and analysis of the dynamics invariably provides an informative point of departure.


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  1. 1.
    Marsh, D.J., J.L. Osborn, and A.W. Cowley Jr. 1/f fluctuations in arterial pressure and the regulation of renal blood flow in dogs. Am. J.Physiol. 258:F1394–F1400, 1990.PubMedGoogle Scholar
  2. 2.
    Schlesinger, M F. Fractal time and 1/f noise in complex systems. Ann. N.Y. Acad. Sci. 504: 214–228,1987.CrossRefGoogle Scholar
  3. 3.
    Mandelbrot, B.B. Fractals Form, Chance and Dimension. San Francisco, 1977, W.H. Freeman and Co.Google Scholar
  4. 4.
    Blinowska, K and Marsh, D J. Ultra-and Orcadian fluctuations in arterial pressure and EMG in conscious dogs. Am. J. Physiol. 249:R720–R725, 1985.PubMedGoogle Scholar
  5. 5.
    Livnat, A., Zehr, J E. and Broten, T P. Ultradian oscillations in blood pressure and — heart rate in free-running dogs. Am. J. Physiol. 246:R817–E824, 1984.PubMedGoogle Scholar
  6. 6.
    Sakai, T., E. Haliman, and D.J. Marsh. Frequency domain analysis of renal autoregu-lation in the rat. Am. J. Physiol. 250: F364–F373, 1986.PubMedGoogle Scholar
  7. 7.
    Hoistein-Rathlou, N.-H., and D.J. Marsh. Oscillations of tubular pressure, flow, and distal chloride concentration in rats. Am. J. Physiol. 256: F1007–F1014, 1989.Google Scholar
  8. 8.
    Leyssac, P.P. Further studies on oscillating tubulo-glomerular feedback responses in the rat kidney. Acta Physiol. Scand. 58:236–242, 1986.CrossRefGoogle Scholar
  9. 9.
    Holstein-Rathlou, N-H. Synchronization of proximal intratubular pressure oscillations: evidence for interaction between nephrons. Pflugers Arch. 408: 438–443, 1987.CrossRefPubMedGoogle Scholar
  10. 10.
    Holstein-Rathlou, N-H., and P.P. Leyssac. Oscillations in proximal intratubular pressure: a mathematical model. Am.J. Physiol. 252: F560–F572, 1987.PubMedGoogle Scholar
  11. 11.
    Leyssac, P.P., and N.-H. Holstein-Rathlou. Effects of various transport inhibitors on oscillating TGF pressure responses in the rat. Pflügers Archiv. 407: 285–2911, 1986.CrossRefPubMedGoogle Scholar
  12. 12.
    Holstein-Rathlou, N.-H., and D.J. Marsh. A dynamic model of the tubuloglomerular feedback mechanism. AmJ.Physiol. 258: F1448–F1459, 1990.Google Scholar
  13. 13.
    Briggs, J.P., G. Schubert, and J. Schnermann. Quantitative characterisation of the tubuloglomerular feedback response: effect of growth. Am. J. Physiol. 247: F808–F815, 1984.PubMedGoogle Scholar
  14. 14.
    Grassberger, P., and I. Procaccia. Measuring the strangeness of strange atractors. Physica 9D:189–208, 1983.Google Scholar
  15. 15.
    Leyssac, P.P. and N.-H. Holstein-Rathlou. Tubuloglomerular feedback: enhancement in spontaneously hypertensive rats and effects of anesthetics. Pflügers Archiv. 413: 267–272, 1989.CrossRefPubMedGoogle Scholar
  16. 16.
    Holstein-Rathlou, N.-H., P. Christensen, and P.P. Leyssac. Effects of halothane-nitrous oxide inhalation anesthesia and Inactin on overall renal and tubular function in Sprague-Dawley and Wistar rats. Acta Physiol. Scand. 114:193–201, 1982.CrossRefPubMedGoogle Scholar
  17. 17.
    Jensen, K.S., N.-H. Holstein-Rathlou, P.P. Leyssac, E. Mosekilde, and D.R. Rasmussen. Chaos in a system of interacting nephrons, in Chaos in Biological Systems., H. Degn, A.V. Holden, and L.F. Olsen, eds. Plenum Publishing Corp. London, 1987.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Donald J. Marsh
    • 1
    • 2
  • N.-H. Holstein-Rathlou
    • 1
    • 2
  • K.-P. Yip
    • 1
    • 2
  • Paul P. Leyssac
    • 1
    • 2
  1. 1.Department of Physiology and BiophysicsUniversity of Southern CaliforniaLos AngelesUSA
  2. 2.Institute for Experimental Medicine, Panum InstitutCopenhagen UniversityCopenhagenDenmark

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