Gangliosides as Receptors for Bacterial Toxins and Sendai Virus

  • J. Holmgren
  • H. Elwing
  • P. Fredman
  • Ö. Strannegård
  • L. Svennerholm
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 125)


Gangliosides have recently attracted considerable interest as candidate receptor structures for various bacterial toxins, viruses, interferon and glycoprotein hormones. Speculations about a receptor role for gangliosides have occurred for more than two decades but it was first with the more recent work on cholera toxin that such a function could be shown.


Adenylate Cyclase Cholera Toxin Sialic Acid Residue Tetanus Toxin Sendai Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. BOURGUIGNON L.Y.W. and SINGER S.J. (1977): Transmembrane interactions and the mechanism of capping of surface receptors by their specific ligands. Proc. Natl. Acad. Sci. (USA), 74, 5031–5035.CrossRefGoogle Scholar
  2. CUATRECASAS P. (1973a): Interaction of Vibrio cholerae enterotoxin with cell membranes. Biochemistry 12, 3547–3558.PubMedCrossRefGoogle Scholar
  3. CUATRECASAS P. (1973b): Gangliosides and membrane receptors for cholera toxin. Biochemistry 12, 3558–3566.PubMedCrossRefGoogle Scholar
  4. FISHMAN P.H., MOSS J. and OSBORNE J.C. (1978): Interaction of choleragen with the oligosaccharide of ganglioside GM1: Evidence for multiple oligosaccharide binding sites. Biochemistry 17, 711–716.PubMedCrossRefGoogle Scholar
  5. GETHING M.J., WHITE J.M. and WATERFIELD M.D. (1978): Purification of the fusion protein of Sendai virus: Analysis of the NH2terminal sequence generated during precurson activation. Proc. Natl. Acad. Sci. ( USA ), 75, 2737–2740.CrossRefGoogle Scholar
  6. GILL D.M. and ENOMOTO K. (1979): Intracellular, enzymic action of enterotoxins: The biochemical basis of cholera. In “43rd Nobel Symposium: Cholera and related diarrheas. Molecular aspects on a global health problem”, Ouchterlony Ö, and Holmgren J., eds., Karger, Basel.Google Scholar
  7. HANSSON H.-A., HOLMGREN J. and SVENNERHOLM L. (1977): Ultra-structural localization of cell membraneGM1 ganglioside by cholera toxin. Proc. Natl. Acad. Sci. 74, 782–3786.CrossRefGoogle Scholar
  8. HART D.A. (1975): Evidence for the non-protein nature of the receptor for the enterotoxin of Vibrio cholerae on murine lymphoid cells. Infect. Immun. 11, 742–747.PubMedGoogle Scholar
  9. HAYWOOD A.M. (1974): Characteristics of Sendai virus receptors in a model membrane. J. Mol.Biol. 83, 427–436.PubMedCrossRefGoogle Scholar
  10. HELENIUS A., MOREIN B., FRIES E., SIMONS K., ROBINSON P., SCHIRRMACHER V., TERHORST C. and STROMINGER J.L. (1978): Human (HLA-A and HLA-B) and murine (H-2K and H2-D) histocompatibility antigens are cell surface receptors for Semliki Forest virus. Proc. Natl. Acad. Sci. ( USA ), 75, 3846–3850.CrossRefGoogle Scholar
  11. HELTING T.B., ZWISLER O. and WIEGANDT H. (1977): Structure of tetanus toxin. II. Toxin binding to ganglioside. J. Biol. Chem. 252, 194–198.PubMedGoogle Scholar
  12. HOLMGREN J. and LÖNNROTH I. (1976): Cholera toxin and the adenylate cyclase-activating signal. J. Infect. Dis. 133, 64–74.PubMedCrossRefGoogle Scholar
  13. HOLMGREN J. and LÖNNROTH I. (1979): Structure and function of enterotoxins and their receptors. In “43rd Nobel Symposium: Cholera and Related Diarrheas. Molecular aspects on a global health problem”, Ouchterlony Ö. and Holmgren J., eds., Karger, Basel.Google Scholar
  14. HOLMGREN J., LÖNNROTH I. and SVENNERHOLM L. (1973): Tissue receptor for cholera exotoxin: Postulated structure from studies with GM7 ganglioside and related glycolipids. Infect. Immun. 8, 208–14.PubMedGoogle Scholar
  15. HOLMGREN J., MANSSON J.-E. and SVENNERHOLM L. (1974): Tissue receptor for cholera exotoxin: Structural requirements of GM1 ganglioside in toxin binding and inactivation. Medical Biology 52, 229–233.PubMedGoogle Scholar
  16. HOLMGREN J., LÖNNROTH I., MANSSON J.E. and SVENNERHOLM L. (1975): Interaction of cholera toxin and membrane Gm.,ganglioside of small intestine. Proc. Natl. Acad. Sci. USA, 72, 2520–2524.PubMedCrossRefGoogle Scholar
  17. KING C.A. and VAN HEYNINGEN W.E. (1973): Deactivation of cholera toxin by a sialidase-resistant monosialosyl-ganglioside. J. Infect. Dis. 127, 639–647.PubMedCrossRefGoogle Scholar
  18. LEDLEY F.D., LEE G., KOHN L.D., HABIG W.H. and HARDEGREE M.C. (1977): Tetanus toxin interactions with thyroid plasma membranes. Implications for structure and function of tetanus toxin receptors and potential pathophysiological significance. J. Biol. Chem. 252, 4049–4055.PubMedGoogle Scholar
  19. LÖNNROTH I. and HOLMGREN J. (1973): Subunit structure of cholera toxin. J. Gen. Microbiol. 76, 417–427.PubMedCrossRefGoogle Scholar
  20. MOSS J., FISHMAN P.H., MANGANIELLO V.C., VAUGHAN M. and BRADY R.O. (1976): Functional incorporation of ganglioside into intact cells: Induction of choleragen responsiveness. Proc. Natl. Acad. Sci. ( USA ), 73, 1034–1037.CrossRefGoogle Scholar
  21. MOSS J., RICHARDS R.L., ALVING C.R. and FISHMAN P.H. (1977): Effect of the A and B protomers of choleragen on release of trapped glucose from liposomes containing or lacking ganglioside GM1. J. Biol. Chem. 252, 797–798.PubMedGoogle Scholar
  22. MULLIN B.R., FISHMAN P.H., LEE G., ALOJ S.M., LEDLEY F.D., WINAND R.J., KOHN L.D. and BRADY R.O. (1976): Thyrotropinganglioside interactions and their relationship to the structure and function of thyrotropin receptors. Proc. Natl. Acad. Sci. ( USA ), 73, 842–846.CrossRefGoogle Scholar
  23. MULLIN B.R., PACUSZKA T., LEE G., KOHN L.D., BRADY R.O. and FISHMAN P.H. (1978): Thyroid gangliosides with high affinity for thyrotropin: Potential role in thyroid regulation. Science 199, 77–79.PubMedCrossRefGoogle Scholar
  24. PRICE D.L., GRIFFIN J.W. and PECK K. (1977): Tetanus toxin: evidence for binding at presynaptic nerve endings. Brain Res. 121, 379–384.PubMedCrossRefGoogle Scholar
  25. SATTLER J., SCHWARZMANN G., STAERK J., ZIEGLER W. and WIEGANDT H. (1977): Studies of the ligand binding to cholera toxin. HoppeSeyler-s Z. Physiol. Chem. 358, 159–163.CrossRefGoogle Scholar
  26. STAERK J., RONNEBERGER H.J., WIEGANDT H. and ZIEGLER W. (1974): Interaction of ganglioside-etl and its derivatives with choleragen. Eur. J. Biochem. 8, 103–110.CrossRefGoogle Scholar
  27. TOSTESON M.T. and TOSTESON D.C. (1978): Bilayers containing gangliosides develop channels when exposed to cholera toxin. Nature (London), 275, 142–144.CrossRefGoogle Scholar
  28. VAN HEYNINGEN W.E., CARPENTER C.C.J., PIERCE N.F. and GREENOUGH W.B. (1971): Deactivation of cholera toxin by ganglioside. J. Infect. Dis. 124, 415–418.PubMedCrossRefGoogle Scholar
  29. VAN HEYNINGEN W.E. and MELLANBY J. (1971): Tetanus toxin. In “Microbiol. toxins, vol 2A, Bacterial protein toxins”. Eds. VAN HEYNINGEN W.E. and MELLANBY J, 69–108, Academix Press (New York).Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • J. Holmgren
    • 1
  • H. Elwing
    • 1
  • P. Fredman
    • 2
  • Ö. Strannegård
    • 1
  • L. Svennerholm
    • 2
  1. 1.Institute of Medical MicrobiologyUniversity of GöteborgGöteborgSweden
  2. 2.Department of NeurochemistryUniversity of GöteborgGöteborgSweden

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