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Perturbation of CNS Functions by Antibodies to Gangliosides. Speculations on Biological Roles of Ganglioside Receptors

  • Maurice M. Rapport
  • Stephen E. Karpiak
  • Sahebarao P. Mahadik
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 125)

Abstract

Since gangliosides are found in the plasma membranes of numerous cell types and interact with apparent specificity with a number of different agents such as toxins, antibodies, and hormones, it is reasonable to regard them as receptor molecules. Our interest in ganglioside receptors stems from their reactions with antibodies. Gangliosides represent only one class of molecules in vertebrate synapses that can be identified as functional components through perturbation of CNS functions by intracerebral administration of antibodies. Since gangliosides are relatively small, stable molecules whose chemistry has been well established, they provide a better focus than other antigenic components of the synapse for developing methods to detect and identify functional molecules. GM1 ganglioside may be especially useful for this purpose since, of the various ganglioside species present in the synaptic membrane, more of the GM1 is exposed on the outer surface and is therefore access-ible to antibodies in the extracellular space.1

Keywords

Passive Avoidance Synaptic Connection Antigenic Component Passive Avoidance Learning Brain Ganglioside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Maurice M. Rapport
    • 1
  • Stephen E. Karpiak
    • 1
  • Sahebarao P. Mahadik
    • 1
  1. 1.Division of Neuroscience, N.Y. State Psychiatric Institute and Departments of Biochemistry and PsychiatryColumbia University College of Physicians and SurgeonsNew YorkUSA

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