Advertisement

Antibodies to Total Brain Gangliosides: Titer and Specificity of Antisera

  • Maurice M. Rapport
  • Liselotte Graf
  • Yung-yu L. Huang
  • William Brunner
  • Robert K. Yu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 125)

Abstract

Our sustained studies of the immunological activity of lipidsl,2 led to the important generalization that such activity was intimately related to glycosphingolipid structures. We therefore had an early interest in the immunological activity of gangliosides and an early appreciation that they exhibited only weak immunogenic properties, much weaker than those of neutral glycosphingolipids.

Keywords

Antibody Titer Total Brain Foreign Agent Brain Ganglioside Brain Gray Matter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Reference

  1. 1.
    RAPPORT, M.M. (1961): J. Lipid Res. 2, 25–36.Google Scholar
  2. 2.
    RAPPORT, M.M. and GRAF, Kallos, P. and Waksman, B.H., eds. Vol. 13, Karger, Basel PP. 273–331Google Scholar
  3. 3.
    PASCAL, T.A., SAIFER, A. Biol. & Med. 121, 739–74Google Scholar
  4. 4.
    RAPPORT, M.M., GRAF, L. and LEDEEN, R (1968): Fed. Proc. 27, 463Google Scholar
  5. 5.
    RAPPORT, M.M., GRAF, L. and LEDEEN, R. (1970): Fed. Proc. 25, 573Google Scholar
  6. 6.
    KARPIAK, S.E., GRAF, L. and RAPPORT, M.M. (1976): Sci. 194, 735–737CrossRefGoogle Scholar
  7. 7.
    KARPIAK, S.E., GRAF, L. and RAPPORT, M.M. (1978): Brain Res. 151, 637–640.PubMedCrossRefGoogle Scholar
  8. 8.
    RAPPORT, M.M. (1973): in “Psychopathology”, Hammer, M.,Salzinger, K.,Sutton, S. eds. John Wiley & Sons, New York, pp. 309–316.Google Scholar
  9. 9.
    KANFER, J.N. (1969): in “Methods in Enzymology”, Lowenstein,J.M., ed. Vol. XIV, Academic Press, N.Y. pp. 660–664.Google Scholar
  10. 10.
    BURTON, R.M. (1963): J. Neurochem. 10, 503–522.Google Scholar
  11. 11.
    SVENNERHOLM, L. and RAAL, A.(1961):3 ochim.Biophys.Acta, 53, 422–424Google Scholar
  12. 12.
    EPSHTEIN, Y. and MARKAEV, T. (1969): Biochemistry (USSR) 34, 735–738Google Scholar
  13. 13.
    ANDO, S. and YU, R.K. (1977): J. Biol. Chem. 252, 6247–6250.PubMedGoogle Scholar
  14. 14.
    WENGER, D.A. and WARDELL, S. (1973): J. Neurochem. 20, 607–612.PubMedCrossRefGoogle Scholar
  15. 15.
    NAIKI, M., MARCUS, D.M. and LEDEEN, R. (1974): J. Immuno1. 113, 84–93Google Scholar
  16. 16.
    KOSCIELAK, J., HAKOMORI, S. and JEANLOZ, R.W. (1968): Immunochem. 5, 441–455.CrossRefGoogle Scholar
  17. 17.
    RAPPORT, M.M. and GRAF, L. (1967): in “Methods in Immunology and Immunochemistry”, Vol. l, Academic Press, New York, pp. 187–196Google Scholar
  18. 18.
    LAEV, H., RAPPORT, M.M., MAHADIK, S.P. and SILVERMAN, A.J. (1978): Brain Res. 157, 136–141PubMedCrossRefGoogle Scholar
  19. 19.
    RAPPORT, M.M. and KARPIAK, S.E. (1978): in “Senile Dementia”, Nandy, K. ed., Elsevier, New York, pp. 73–88Google Scholar
  20. 20.
    MARCUS, D.M. (1977): in “Glycolipid Methodology”, Witting, L.A. ed., Am. Oil. Chem. Soc., Champaign, Illinois, pp. 242–243Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Maurice M. Rapport
    • 1
    • 2
  • Liselotte Graf
    • 1
    • 2
  • Yung-yu L. Huang
    • 1
    • 2
  • William Brunner
    • 1
    • 2
  • Robert K. Yu
    • 1
    • 2
  1. 1.Division of Neuroscience, New York State Psychiatric Institute, Departments of Biochemistry and PathologyColumbia University College of Physicians and SurgeonsNew YorkUSA
  2. 2.Department of NeurologyYale University School of MedicineNew HavenUSA

Personalised recommendations