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Structural Modifications of Gangliosides in Synaptic Membranes

  • K. C. Leskawa
  • A. Rosenberg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 125)

Abstract

It has been hypothesized that neuronal gangliosides are involved in receptors for biogenic amines (1–3) and certain neuro-toxins (4,5), and it is generally, although not universally (6), believed that, in the central nervous system, gangliosides are to be found concentrated in synaptic membranes. For further information, we have prepared purified intact and hypoosmotically ruptured synaptosomes from beef brain in order to probe the structural disposition of gangliosides in these preparations by surface labelling techniques for sialosyl and galactosyl components, and we have made preliminary observations on the modifying influence of calcium ions.

Keywords

Sialic Acid Synaptic Membrane Sialic Acid Residue Synaptosomal Membrane Galactose Oxidase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • K. C. Leskawa
    • 1
  • A. Rosenberg
    • 1
  1. 1.Department of Biological Chemistry The Milton S. Hershey Medical CenterThe Pennsylvania State UniversityHersheyUSA

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