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Correlation Between K+ Fluxes and the Arachidonic Acid Cascade in Human Leukocyte Stimulated with a 23187 or Melittin

  • Monique Braquet
  • Mara d’Onofrio
  • Ricardo Garay
  • Pierre Braquet
Part of the NATO ASI Series book series (NSSA, volume 95)

Abstract

It is well known that leukocytes play key roles in mechanisms of body defense against both endotoxins and exotoxins. The factors involved in triggering such defense mechanisms involve an activation of cellular membrane processes, among which is the release (from phospholipids) of AA and its subsequent metabolism into various icosanoids. The liberation of such icosanoids (e.g. LTs, PGs, HPETEs), in addition to the formation of superoxide and other oxygen free radicals and the liberation of histamine and certain degradative enzymes (e.g., elastase, collagenase), play key roles not only in the destruction of suitable ingestible particles but also in the recruitment (chemotaxic effect) of other cells for this process. All of these events depend upon the generation and transmission of a membrane signal which involves mainly membrane metabolism and ion transport1.

Keywords

Human Leukocyte Leukocyte Activation Arachidonic Acid Cascade Membrane Signal Transient Hyperpolarization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Monique Braquet
    • 1
  • Mara d’Onofrio
    • 2
  • Ricardo Garay
    • 2
  • Pierre Braquet
    • 3
  1. 1.C.R.S.S.A., Division de RadiobiochimieClamartFrance
  2. 2.INSERM U7, Hopital NeckerParisFrance
  3. 3.I.H.B. Research LaboritoriesLe PlessisFrance

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