Stimulated Human Colonic Synthesis of Arachidonate Lipoxygenase and Cyclo-Oxygenase Products by Laxatives
We have recently demonstrated that rat colon can convert 14Carachidonic acid into both lipoxygenase and cyclo-oxygenase products, and that this metabolism is stimulated by the laxative phenolphthalein (Capasso et al 1984). These products can affect intestinal function. Prostaglandins (Bennett and Sanger 1982) and lipoxygenase products (Musch et al 1982) can increase intestinal motility and the secretion of water and electrolytes. Human colon forms similar products (Bennett et al 1981; Boughton-Smith et al 1983), and we have now investigated the effect of laxatives on arachidonic acid metabolism by human isolated colonic mucosa and muscle.
KeywordsArachidonic Acid Ricinoleic Acid Arachidonic Acid Metabolism Lipoxygenase Product Sodium Sulfosuccinate
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- Bennett A, Hensby CN, Sanger GJ, Stamford IF (1981). Metabolites of arachidonic acid formed by human gastrointestinal tissues and their actions on the muscle layers. Br J Pharmac 74: 435Google Scholar
- Bennett A, Sanger GJ (1982). Acidic Lipids; Prostaglandins, in: Handbook of Exp Pharmacol 59/II, Ed G Bertaccini, Springer-Verlag, Berlin, p219Google Scholar
- Beubler E, Juan H (1979). Effect of ricinoleic acid and other laxatives on net water flux and prostaglandin E release by the rat colon. J Pharm Pharmac 31: 681Google Scholar
- Borgeat P, Samuelsson B (1979) Arachidonic acid metabolism in polymorphonuclear luekocytes: unstable intermediate in formation of dihydroxy acids, Proc. Natl Acad Sci USA 76: 3213Google Scholar
- Capasso F, Tavares IA, Bennett A (1984). The production of arachidonic lipoxygenase products by rat intestine is increased by phenolphthalein. Eur J Pharmacol, in pressGoogle Scholar