The Role of Glucocorticoid-Induced Phospholipase Inhibitory Proteins
Glucocorticoids are powerful anti-inflammatory agents. Although their chief clinical utility in the treatment of acute and chronic inflammatory processes the knowledge of the mode of action of gluco -corticoids is still fragmentary. However at least some anti-inflammatory effects of glucocorticoids depend on their ability to prevent the formation of arachidonic acid oxidation products, i.e. the prostaglandins and leukotrienes which are important mediators of the inflammatory response. Glucocorticoids although do not inhibit cyclo-oxygenase or lipoxygenase are able to prevent phospholipid deacylation from occurring in intact cells by inhibiting phospholipase A2 thereby causing a shortage of precursor arachidonic acid.
KeywordsArachidonic Acid Systemic Lupus Erythematosus Patient Histiocytic Lymphoma Dibutyryl Adenosine Severe Rheumatic Disease
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