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Comparative Effects of Leukotrienes in Respiratory Tissue of Various Species

  • Marwa N. Samhoun
  • Priscilla J. Piper
  • Neil C. Barnes
Part of the NATO ASI Series book series (NSSA, volume 95)

Abstract

It is now recognised that leukotrienes (LTs) C4, D4 and their probable metabolite E4, which contain a sulphur linkage and amino acid side chain at C-6, collectively account for the biological activity of slow-reacting substance of anaphylaxis (SRS-A) obtained from various sources which, for many years, has been proposed as an important mediator of bronchoconstriction in man. These LTs display pronounced spasmogenic and vasoactive properties in various preparations and possess unprecedented potencies in respiratory smooth muscle in particularl.

Keywords

Perfuse Lung Human Bronchus Bronchoconstrictor Effect Isolate Perfuse Lung Parenchymal Strip 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Marwa N. Samhoun
    • 1
  • Priscilla J. Piper
    • 1
  • Neil C. Barnes
    • 2
  1. 1.Department of PharmacologyRoyal College of Surgeons of EnglandLondonUK
  2. 2.Chest Unit King’s College Hospital Medical SchoolLondonUK

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