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Drugs Affecting Leukotrienes and Other Eicosanoid Pathways pp 121–129Cite as

Comparative Effects of Leukotrienes in Respiratory Tissue of Various Species

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Part of the book series: NATO ASI Series ((NSSA,volume 95))

Abstract

It is now recognised that leukotrienes (LTs) C4, D4 and their probable metabolite E4, which contain a sulphur linkage and amino acid side chain at C-6, collectively account for the biological activity of slow-reacting substance of anaphylaxis (SRS-A) obtained from various sources which, for many years, has been proposed as an important mediator of bronchoconstriction in man. These LTs display pronounced spasmogenic and vasoactive properties in various preparations and possess unprecedented potencies in respiratory smooth muscle in particularl.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Royal College of Surgeons of England, London, WC2A 3PN, UK

    Marwa N. Samhoun & Priscilla J. Piper

  2. Chest Unit King’s College Hospital Medical School, London, SE5, UK

    Neil C. Barnes

Authors
  1. Marwa N. Samhoun
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  2. Priscilla J. Piper
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  3. Neil C. Barnes
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Editor information

Editors and Affiliations

  1. Karolinska Institute, Stockholm, Sweden

    B. Samuelsson

  2. University of Milan, Milan, Italy

    F. Berti  & G. C. Folco  & 

  3. University of Verona, Verona, Italy

    G. P. Velo

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© 1985 Plenum Press, New York

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Samhoun, M.N., Piper, P.J., Barnes, N.C. (1985). Comparative Effects of Leukotrienes in Respiratory Tissue of Various Species. In: Samuelsson, B., Berti, F., Folco, G.C., Velo, G.P. (eds) Drugs Affecting Leukotrienes and Other Eicosanoid Pathways. NATO ASI Series, vol 95. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7841-9_10

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  • DOI: https://doi.org/10.1007/978-1-4684-7841-9_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7843-3

  • Online ISBN: 978-1-4684-7841-9

  • eBook Packages: Springer Book Archive

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