Comparative Morphology of Macrophages in Tissue Culture
Macrophages were obtained in tissue cultures with cells obtained from mouse lung, spleen, bone marrow, peripheral blood, and peritoneal cavity. In addition, macrophages from lung, spleen, bone marrow, and peritoneal cavity of guinea pigs and rats were also cultivated in vitro. Cells from the rat closely resembled those from the mouse, whereas guinea pig cells differed in several respects. In most instances, cells other than macrophages were phagocytized or died with the result that within seven days the cultures consisted entirely of macrophages. Macrophages from all these sources were actively phagocytic, were present as solitary ameboid cells, and, with the exception of certain guinea pig cells, underwent mitosis.
KeywordsMitotic Rate Comparative Morphology Cytoplasmic Process Peritoneal Cell Bone Marrow Macrophage
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