Atherosclerosis Induced Experimentally By Repeated Intravenous Administration of Hypercholesterolemic Serum and of Lipoproteins
Serum from rabbits rendered hypercholesterolemic by dietary supplement was administered intravenously daily in 10-ml aliquots to four recipient rabbits: one for 5 months (total cholesterol 13.7 g), three for 6–7 months (total cholesterol 22–23 g). All animals showed marked elevation of serum cholesterol and serum β -lipoproteins. The rabbits treated for 6–7 months which received high quantities of cholesterol developed atherosclerotic plaques in the aorta, carotid, and cardial arteries.
The next step included the separation of serum into chylomicrons and lipoproteins and their intravenous injection into other recipient rabbits, for 6 months. Atherosclerosis was induced only in the case when lipoproteins (total cholesterol 24–25 g) were injected.
These data prove directly the atherogenic action of lipoproteins.
KeywordsAtherosclerotic Plaque Serum Cholesterol Atherosclerotic Lesion Aortic Wall Serum Lipoprotein
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