Immunoglobulin Synthesis in the Rat
The synthesis of immunoglobulin consists of a complex series of cellular and molecular reactions beginning soon after the injection of a specific antigen. It is established with some certainty that antigen, following administration, is taken up by macrophages and processed by these cells. A stimulus is then transmitted in a still undetermined manner to immunocompetent, undifferentiated reticular cells. These begin dividing very rapidly and give rise to differentiated lymphoid cells which are the main antibody producers. The serum antibody titer begins to rise around the third day after primary immunization, reaches a peak by the end of the first week, and then declines slowly. A second injection of antigen is followed by a more rapid rise and a slower decline of antibody titer [1–4].
KeywordsSpleen Cell Liquid Scintillation Spectrometer Amino Acid Analog Antibody Synthesis Serum Antibody Titer
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