Immunoglobulin Synthesis in the Rat

  • Mariano F. La Via
  • William S. Hammond
  • Barbara H. Iglewski
  • Albert E. Vatter
  • Michael Bean
  • Patricia V. Northup
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1)


The synthesis of immunoglobulin consists of a complex series of cellular and molecular reactions beginning soon after the injection of a specific antigen. It is established with some certainty that antigen, following administration, is taken up by macrophages and processed by these cells. A stimulus is then transmitted in a still undetermined manner to immunocompetent, undifferentiated reticular cells. These begin dividing very rapidly and give rise to differentiated lymphoid cells which are the main antibody producers. The serum antibody titer begins to rise around the third day after primary immunization, reaches a peak by the end of the first week, and then declines slowly. A second injection of antigen is followed by a more rapid rise and a slower decline of antibody titer [1–4].


Spleen Cell Liquid Scintillation Spectrometer Amino Acid Analog Antibody Synthesis Serum Antibody Titer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    M.F. LaVia, F.W. Fitch, C.H. Gunderson, and R.W. Wissler, in: J. H. Heller, Ed., Reticuloendothelial Structure and Function. New York, Ronald Press, 1960.Google Scholar
  2. 2.
    J.W. Uhr, Science, 145: 157, 1964.CrossRefGoogle Scholar
  3. 3.
    G.J. Nossal, Intern. Rev. Exptl. Pathol., 1: 1, 1962.CrossRefGoogle Scholar
  4. 4.
    G. J. Nossal, G. C. Ada, and C. M. Austin, Australian J. Exptl. Biol. Med. Sci., 42: 311, 1964.CrossRefGoogle Scholar
  5. 5.
    D.A. Rowley, J. Immunol., 64: 289, 1950.PubMedGoogle Scholar
  6. 6.
    J. Winebright and F.W. Fitch, J. Immunol., 89: 891, 1962.PubMedGoogle Scholar
  7. 7.
    P.A. Campbell and M. F. LaVia, Proc. Soc. Exptl. Biol. Med., 124: 571, 1967.Google Scholar
  8. 8.
    R. W. Wissler, F. W. Fitch, M. F. LaVia, and C. H. Gunderson, J. Cell. Comp. Physiol., 50, Suppl. 1: 265, 1957.CrossRefGoogle Scholar
  9. 9.
    C.H. Gunderson, D. Juras, M.F. LaVia, and R.W. Wissler, J. Am. Med. Assoc., 180: 1038, 1962.CrossRefGoogle Scholar
  10. 10.
    M.F. LaVia, J. Immunol.,. 92: 252, 1964.PubMedGoogle Scholar
  11. 11.
    M. Fishman, J.J. van Rood, and F.B. Adler, in: J. Sterzl, Ed., Molecular and Cellular Basis of Antibody Formation. New York, Academic Press, 1964.Google Scholar
  12. 12.
    B.A. Askonas and J.M. Rhodes, in: J. Sterzl, Ed., Molecular and Cellular Basis of Antibody. Formation. New York, Academic Press, 1964.Google Scholar
  13. 13.
    W. H. Taliaferro and D.W. Talmage, J.Infect. Diseases, 97: 88, 1955.CrossRefGoogle Scholar
  14. 14.
    R. S. Schwarz, Progr.Allergy, 9: 246, 1965.Google Scholar
  15. 15.
    S. Tawde, M.D. Scharff, and J.W. Uhr, J.Immunol., 96: 1, 1966.PubMedGoogle Scholar
  16. 16.
    M. F. LaVia, A. E. Vatter, and P. V. Northup, Exptl. Mol. Pathol., Supp1. 3: 124, 1966.Google Scholar
  17. 17.
    W.S. Hammond, M. Bean, and M.F. LaVia, In preparation.Google Scholar
  18. 18.
    M.F. LaVia, Proc. Soc. Exptl. Biol. Med., 114: 133, 1963.Google Scholar
  19. 19.
    P.R. Cannon, W.E. Chase, and R.W. Wissler, J.Immunol., 47: 133, 1943.Google Scholar
  20. 20.
    P.R. Cannon, Ann. Surg., 120: 514, 1944.PubMedGoogle Scholar
  21. 21.
    B. Mach and P. Vassalli, Proc. Nat. Acad. Sci. U. S., 54: 975, 1965.CrossRefGoogle Scholar
  22. 22.
    P. V. Northup, W. S. Hammond, and M. F. La Via, Proc. Nat. Acad. Sci. U. S., 57: 273, 1967.CrossRefGoogle Scholar
  23. 23.
    M.F. LaVia, A. E. Vatter, W.S. Hammond, and P. V. Northup, Proc. Nat. Acad. Sci. U. S., 57: 79, 1967.CrossRefGoogle Scholar
  24. 24.
    L. Hood, W. Gray, and W. Dreyer, Proc. Nat.Acad. Sci. U. S., 55: 826, 1966.CrossRefGoogle Scholar
  25. 25.
    A.A. Gottlieb, in: “Differentiation and growth of hemoglobin and immunoglobulin-synthesizing cells,” J. Cell Physiol., 67, Supp1.1: 164, 1966.Google Scholar
  26. 26.
    A. Rich, J.R. Warner, and H. M. Goodman, Cold Spring Harbor Symp. Quant. Biol., 28: 269, 1963.CrossRefGoogle Scholar
  27. 27.
    P. Pfuderer, P. Cammarano, D.R. Holladay, and G.D. Novelli, Biochim.Biophys.Acta, 109: 595, 1965.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1967

Authors and Affiliations

  • Mariano F. La Via
    • 1
  • William S. Hammond
    • 1
  • Barbara H. Iglewski
    • 1
  • Albert E. Vatter
    • 1
  • Michael Bean
    • 1
  • Patricia V. Northup
    • 1
  1. 1.Department of PathologyUniversity of Colorado Medical CenterDenverUSA

Personalised recommendations