The Effect of Opsonized Colloids on the Enhancement of Endotoxin Lethality

  • I. MacKay Murray
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1)


The diverse physiologic functions which are altered following the intravenous injection of inert particles, have imposed, a priori, on the reticuloendothelial system (RES) a significance which belies its morphological appearance. This is exemplified by the striking increase in the sensitivity of several species of animals to the lethal effects of endotoxin when given within a definite interval of time after the intravenous injection of colloidal material [1]. Since the majority of these colloidal particles are phagocytized by the fixed reticuloendothelial cells of the liver and spleen, it has been suggested [2] that the functions of the RE cells are impaired for a variable period of time due to the presence of a mass of inert material contained within their cytoplasm. Blockaded RE cells would be temporarily unable to phagocytose additional foreign material such as endotoxins.


Clearance Rate Reticuloendothelial System Inert Particle Natural Antibody Phagocytic Capacity 
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Copyright information

© Springer Science+Business Media New York 1967

Authors and Affiliations

  • I. MacKay Murray
    • 1
  1. 1.Department of AnatomyState University of New York Downstate Medical CenterBrooklynUSA

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