Comparative Effect of Endotoxin and Reticuloendothelial “Blocking” Colloids on Selected Inducible Liver Enzymes

  • L. Joe Berry
  • Manjul K. Agarwal
  • Irvin S. Snyder
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1)


The LD50 of endotoxin lowers the activity of the hormonally inducible mouse liver enzyme tryptophan pyrrolase to less than one-half the control value and keeps it at a depressed level for about 24 hr. Endotoxin, by contrast, increases the activity of a similarly inducible liver enzyme, tyrosine-α-ketoglutarate transaminase. Endotoxin also prevents the induction of tryptophan pyrrolase by cortisone but does not prevent the induction of the transaminase. Either zymosan or glucan exerts an effect similar to endotoxin on both enzymes, except that the colloids do not prevent induction by cortisone. Both enzymes in mice made tolerant to endotoxin are less subject to change by endotoxin or zymosan than in normal mice. In animals given a series of injections of zymosan or saccharated iron oxide this does not occur.


Bryn Mawr Hormonal Induction Cortisone Acetate Iowa College Tolerant Mouse 


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Copyright information

© Springer Science+Business Media New York 1967

Authors and Affiliations

  • L. Joe Berry
    • 1
  • Manjul K. Agarwal
    • 1
  • Irvin S. Snyder
    • 1
  1. 1.Department of BiologyBryn Mawr CollegeBryn MawrUSA

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