The Dissimilar Effects of Two RES Stimulants on Shock

  • Gottfried Lemperle
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1)


During the past decade, various agents have been found to stimulate some of the manifold functions of the RES. In animal experiments, an increased state of resistance to certain infections and transplantable tumors after the injection of these agents has often been demonstrated. On the other hand, host defense mechanisms may be adversely influenced by various diseases or injuries. There is evidence that at least some of the functions of the RES are significantly depressed during and after a period of severe traumatic shock. It seems logical that a rise in RES activity may prevent or equalize its depression. Paradoxically, most of the well-known stimulating agents such as BCG [1, 2], pertussis vaccine [3], zymosan [4, 5], triolein [6], and glucan (v. infra) render the animals increasingly susceptible to various forms of shock or endotoxin injections. Only pretreatment with endotoxin provides tolerance toward shock or otherwise lethal doses of endotoxin.


Lysosomal Membrane Pertussis Vaccine Liver Glycogen Bacterial Endotoxin Endotoxin Shock 
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Copyright information

© Springer Science+Business Media New York 1967

Authors and Affiliations

  • Gottfried Lemperle
    • 1
  1. 1.New England Institute for Medical ResearchRidgefieldUSA

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