Cytodynamics of Rat Lung in Response to Freund’s Adjuvant

  • Louis J. Casarett
  • George V. Metzger
  • Margaret G. Casarett
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1)


This study is part of a larger series related to the origin of the alveolar macrophage and the responsivity of alveolar cells to injected and inhaled stimuli. Alveolar epithelial proliferation has been measured by use of tritiated thymidine in rats which had received one or two injections of Freund’s adjuvant. An increase in the rate of DNA synthesis accompanied the proliferative response. Histological and ultrastructural observations are summarized briefly. A similar increase in numbers of alveolar epithelial cells entering mitosis is reported following inhalation of about 25 or 50 µg Fe2O3 dust.


Alveolar Macrophage Alveolar Epithelial Cell Alveolar Epithelium Alveolar Wall Alveolar Cell 


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Copyright information

© Springer Science+Business Media New York 1967

Authors and Affiliations

  • Louis J. Casarett
    • 1
  • George V. Metzger
    • 1
  • Margaret G. Casarett
    • 1
  1. 1.Department of Radiation Biology and BiophysicsUniversity of Rochester Medical CenterRochesterUSA

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