Abstract
This study is part of a larger series related to the origin of the alveolar macrophage and the responsivity of alveolar cells to injected and inhaled stimuli. Alveolar epithelial proliferation has been measured by use of tritiated thymidine in rats which had received one or two injections of Freund’s adjuvant. An increase in the rate of DNA synthesis accompanied the proliferative response. Histological and ultrastructural observations are summarized briefly. A similar increase in numbers of alveolar epithelial cells entering mitosis is reported following inhalation of about 25 or 50 µg Fe2O3 dust.
This work was performed under AEC contract W-7401-ENG-49. The technical assistance of Terry McMahon and Karl Emilson is gratefully acknowledged.
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References
P. E. Morrow, “Some physical and physiological factors controlling the fate of inhaled substances. I. Deposition.” Health Phys., 2: 379–386, 1960.
L. J. Casarett, “Some physical and physiological factors controlling the fate of inhaled substances. II. Retention. ” Health Phys., 2: 379–386, 1960.
International Commission on Radiation Protection, Committee II. Report by Task Group on Lung Dynamics, P. E. Morrow, Chairman. Health Phys., 12: 173–208, 1966.
C.W. LaBelle and H. Brieger, “Basic physiologic mechanisms in the pulmonary response to inhaled particulates.” Intern. Congr. on Occup. Health, 13th, 730–735, 1960.
G. W. H. Schepers, T.M. Durkan, A.B. Delahant, F.T. Creedon, and A.J. Redlin, “The biological action of Degussa submicron amorphous silica dust.” Arch.Ind. Health, 16: 125–146, 1957.
L. J. Casarett and P. S. Milley, “Alveolar reactivity following inhalation of particles.” Health Phys., 10: 1003–1011, 1964.
L.J. Casarett, “Distribution and excretion of polonium-210. XII. Auto-radiographic observations after inhalation of Po-210. ” Radiation Res. Suppl., 5: 187–204, 1964.
P. E. Morrow and L. J. Casarett, “An experimental study of the deposition and retention of a plutonium-239 dioxide aerosol,” in: Inhaled Particles and Vapors, New York, Pergamon Press, 1961, pp. 167–175.
M. R. Hilleman, “A forward look at viral vaccines. ” Am. R.v. Respirat.Diseases, 90: 683–706, 1964.
J. Freund, “The mode of action of immunologic adjuvants. ” Advan. Tuberc.Res., 7: 130–142, 1956.
J. W. Steiner, B. Langer, and D. L. Schotz, “The local and systemic effects of Freund’s adjuvant and its fractions. ” Arch. Pathol., 70: 424–434, 1960.
A. Laufer, C. Tal, and A.J. Behar, “Effect of adjuvant (Freund’s type) and its components on the organs of various animal species. ” Brit. J. Exptl. Pathol., 40: 1–7, 1959.
J. C. Ruggs, R.D. Moore, and M.D. Schoenberg, “Stimulation of the reticuloendothelial system in the rabbit by Freund’s adjuvant. ” Arch. Pathol., 70: 43–49, 1960.
R.D. Moore and M.D. Schoenberg, “Modification of cellular proliferation of the reticuloendothelial system in the rabbit.” Exptl. Cell Res., 30: 301–310, 1963.
R.D. Moore and M.D. Schoenberg, “Alveolar lining cells and pulmonary reticuloendothelial system of the rabbit.” Am. J. Pathol., 45: 991–1006, 1964.
F.D. Bertalanffy and C. P. Leblond, “The continuous renewal of the two types of alveolar cells in the lung of the rat.” Anat. Rec., 115: 515–542, 1953.
H. Bacchus, “Cytochemical study of the adrenal cortex of the rat under salt stresses. ” Am. J. Physiol., 163: 326–331, 1950.
L. J. Leach, “A laboratory test chamber for studying airborne materials. ” University of Rochester Atomic Energy Project Report, UR-629, 1963.
J. C. Briscoe, “An experimental investigation of the phagocytic action of the alveolar cells of the lung. ” J. Pathol. Bacteriol., 12: 66–100, 1908.
W.T. Sewell, “The phagocytic properties of the alveolar cells of the lung. ” J. Pathol. Bacteriol., 22: 40–55, 1918.
H. M. Carleton, “The pulmonary lesions produced by the inhalation of dusts in guinea pigs.” J. Hyg., 22: 438–472, 1924.
L. J. Casarett, P. E. Morrow, and F. R. Gibb, “Autoradiographic study of the distribution of plutonium-239 following inhalation. ” Industrial Health Conference, Chicago (Abstract), 1959.
V. E. Krahl, “The expansion of pulmonary alveoli in the newborn mouse. Motion pictures. ” Anat. Rec., 115: 448 (Abstract), 1953.
V. E. Krahl, “Current concept of the finer structure of the lung. ” Arch. Internal Med., 96: 342–356, 1955.
C. Nagaishi, Y. Okada, S. Ishiko, and S. Daido, “Electron microscopic observations of the pulmonary alveoli. ” Exptl. Med. Surg. 22: 81–117, 1964.
H. Kitamura, “The fine structure of lung alveoli and its reactions.” Acta Pathol. Japan., 14: 147–167, 1964.
H. E. Karrer, “The ultrastructure of mouse lung; general architecture of capillary and alveolar walls. ” J. Biophys. Biochem. Cytol., 2: 241–252 (1956).
H. E. Karrer, “The ultrastructure of the mouse lung; the alveolar macrophage. ” J. Biophys. Biochem. Cytol., 4: 693–700, 1958.
H. E. Karrer, “Electron microscopic study of the phagocytic process in lung. ” J. Biophys. Biochem. Cytol., 7: 357–366, 1960.
F. N. Low and M.M. Sampaio, “The pulmonary alveolar epithelium as an entodermal derivative. ” Anat. Rec., 127: 51–64, 1957.
R. G. Shorter, J. L. Titus, and M. B. Divertie, “Cell turnover in the respiratory tract.” Diseases Chest, 46: 138–142, 1964.
I. S. Ross, “Pulmonary epithelium and proliferative reactions in the lungs.” Arch. Pathol., 27: 478–496, 1939.
L.J. Casarett and B. Epstein, “Deposition and fate of inhaled iron-59 oxide in rats. ” Am. Ind. Hyg. Assoc. J. (in press, 1966).
C.W. LaBelle and H. Brieger, “Synergistic effects of aerosols. H. Effects on rate of clearance from the lung. ” Arch.Ind. Health, 20: 100–105, 1959.
J. Ferin, G. Urbonkova, and A. Vlckova, “Pulmonary clearance and the function of macrophages. ” Arch. Environ. Health, 10: 790–795, 1965.
P. E. Morrow, F.R. Gibb, and L. Johnson, “Clearance of insoluble dust from the lower respiratory tract. ” Health Phys., 10: 543–555, 1964.
G. L. Woodside and A. J. Dalton, “The ultrastructure of lung tissue from newborn and embryo mice.” J. Ultrastruct. Res., 2: 28, 1958.
P.E. Morrow, M. Fisher, and F. R. Gibb, “The use of lung analogs in the study of pulmonary clearance mechanisms. ” John A. Hartford Foundation Conference on Air Pollution and the Lung, NYU and Bellevue Hospital, 1966.
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Casarett, L.J., Metzger, G.V., Casarett, M.G. (1967). Cytodynamics of Rat Lung in Response to Freund’s Adjuvant. In: Luzio, N.R.D., Paoletti, R. (eds) The Reticuloendothelial System and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7796-2_11
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DOI: https://doi.org/10.1007/978-1-4684-7796-2_11
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