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Genetic Control of Drug Metabolism

  • Daniel W. Nebert
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 97)

Abstract

To study the genetic control of drug metabolism is often called pharmacogenetics. In a single sentence, “pharmacogenetics” may be defined as the attempt to understand why the same dose of the same drug given to two different individuals (with the possible exception of identical twins) may cause widely varying responses. These “responses” include therapeutic effects of a drug, e.g. anticoagulation or control of seizures, but also unwanted deleterious effects such as cancer or drug toxicity. The experimental system to be examined in detail in this Chapter represents principally a genetic difference in receptor concentration; because of this defect there are large genetic differences in the biotransformation and pharmacokinetics of certain drugs and other environmental pollutants, resulting in important differences in risk toward cancer, drug toxicity, mutation, and birth defects.

Keywords

Inbred Strain Inbred Mouse Strain Bronchogenic Carcinoma Monooxygenase Activity Polycyclic Hydrocarbon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York  1978

Authors and Affiliations

  • Daniel W. Nebert
    • 1
  1. 1.Developmental Pharmacology Branch, NICHDNational Institutes of HealthBethesdaUSA

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