Simulation of Skin Oxygen Supply with Heat Induced Hyperemia
In the last years skin oxygen supply has become of particular interest, since the transcutaneous PO2 measuring technique has been introduced in clinics as a diagnostic tool. The basis of a correct application of this measuring technique is the understanding of the oxygen exchange processes through the upper skin. As in other organs, the O2 supply by blood can be described by the circulatory hyperbola, but the gas exchange from blood to tissue is different in the upper skin, since the subpapillary capillaries have a hair pin-like shape. Only the dare of these capillary loops canes in close contact to the epidermal layer. Since the limbs of the loops are close together, oxygen shunt diffusion is expected to occur. The experiments of Huch et al (1973, 1975) showed that for correct measurements a large hyperemia is necessary and that this hyperemia can only be brought about by local hyperthermia. The hyperthermia influences the O2 exchange processes especially by changing the O2 dissociation curve of hemoglobin.
KeywordsSkin Surface Stratum Granulosum Arterial Limb Oxygen Dissociation Curve Venous Limb
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